Severe acute pancreatitis (SAP) is an inflammatory disease of the pancreas accompanied
by tissue injury and necrosis. It not only affects the pancreas but also triggers a systemic …

Insulin resistance (IR) is one of the essential conditions in the development of type 2
diabetes mellitus (T2DM). IR occurs in hepatic cells when the insulin receptor substrate-1 …

Sepsis has affected millions of people worldwide with high mortality rate and lack of effective
strategies. Previous studies have reported that quercetin (Que) can attenuate …

Osteoarthritis (OA) is a degenerative articular cartilage pathogenic process that is
accompanied by excessive chondrocyte apoptosis. The occurrence of chondrocyte death …

A failure in immune tolerance leads to autoimmune destruction of insulin-producing β-cells,
leading to type 1 diabetes (T1D). Inhibiting autoreactive T cells and inducing regulatory T …

Obesity-induced insulin resistance is the hallmark of metabolic syndrome, and chronic, low-
grade tissue inflammation links obesity to insulin resistance through the activation of tissue …

Antioxidants play an early intervention role in the pathogenesis of kidney injury by
alleviating oxidative damage to the injured kidney. The development of safe and effective …

Retinal ischemia-reperfusion (I/R) injuries are involved in the universal pathological
processes of many ophthalmic diseases, including glaucoma, diabetic retinopathy, and …

Complications arising from diabetes can threaten multiple organs. Advanced glycation end
products (AGEs) play a significant role in inducing these complications. Highly processed …

Astrocytes, as the most plentiful subtypes of glial cells, play an essential biphasic function in
ischemic stroke (IS). However, although having beneficial effects on stroke via promoting …