Chronic cocaine use reduces glutamate levels in the nucleus accumbens (NAc), and is
associated with experience‐dependent changes in (±)‐α‐amino‐3‐hydroxy‐5 …

Chronic cocaine use produces numerous biological changes in brain, but relatively few are
functionally associated with cocaine reinforcement. Here we show that daily intravenous …

Glutamate signaling in the nucleus accumbens influences reinstatement of previously
extinguished cocaine-seeking behavior in rats. Whether or not region specific glutamate …

Regulation of AMPA receptor trafficking is important for many forms of neuronal plasticity. In
this study, a protein cross-linking assay was used to evaluate the contribution of AMPA …

Background The development and persistence of addiction is mediated in part by drug-
induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors …

Cocaine-induced plasticity of mesocorticolimbic dopamine (DA) neurons, originating in the
ventral tegmental area (VTA), persists in the absence of cocaine and may contribute to both …

Drugs of abuse increase the frequency and magnitude of brief (1–3 s), high concentration
(phasic) dopamine release events in terminal regions. These are thought to be a critical part …

Cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the
synaptic delivery of GluR1-containing AMPA receptors. This cocaine-evoked plasticity …

Substance dependence is characterized by a group of symptoms, according to the
Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV …

Addiction is associated with changes in synaptic plasticity mediated, in part, by alterations in
the trafficking and stabilization of AMPA receptors at synapses within the nucleus …