The role of adaptive immunity in early cancer development is controversial. Here we show
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …

Hepatocellular carcinoma (HCC) represents a classic example of inflammation-linked
cancer. To characterize the role of the immune system in hepatic injury and tumor …

B cells are prominent components of human solid tumours, but activation status and
functions of these cells in human cancers remain elusive. Here we establish that over 50% B …

Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to
the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer …

Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to
directly recognize and kill tumour cells,–. These strategies are limited by the emergence of …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …

Lymphocytes were originally thought to form the basis of a 'cancer immunosurveillance'
process that protects immunocompetent hosts against primary tumour development,, but this …

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death.
Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the US population and …

The liver is bathed in bacterial products, including lipopolysaccharide transported from the
intestinal portal vasculature, but maintains a state of tolerance that is exploited by persistent …

In contrast to most other malignancies, hepatocellular carcinoma (HCC), which accounts for
approximately 90% of primary liver cancers, arises almost exclusively in the setting of …