Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …

High fat diet, as an important risk factor, plays a pivotal role in atherosclerotic process.
Celastrol is one of the active triterpenoid compounds with antioxidative and anti …

Celastrol, a triterpenoid derived from traditional Chinese medicinal plants, has anti-
inflammatory, antioxidant, and anticancer activities. Celastrol has shown …

Celastrol, a compound extracted from traditional Chinese medicine, has been reported as a
potent anti-obesity agent with controversial mechanisms. Here both C57BL/6J and leptin …

Despite all modern advances in medicine, an effective drug treatment of obesity has not
been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity …

The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …

In the recent years, much attention has been focused on identifying bioactive compounds
from medicinal plants that could be employed in therapeutics, which is attributed to their …

Overweight and obesity may cause several metabolic complications, including type 2
diabetes mellitus and hyperlipidemia. Despite years of progress in medicine, there are no …

Cardiovascular diseases (CVD) are leading causes of morbidity and mortality worldwide;
therefore, seeking effective therapeutics to reduce the global burden of CVD has become …

Objective Celastrol, a triterpene from the root bark of the Chinese medicinal plant
Tripterygium wilfordii, has been shown to exhibit anti-oxidant, anti-inflammatory, anti-cancer …