Safe oral triiodo-L-thyronine therapy protects from post-infarct cardiac dysfunction and arrhythmias without cardiovascular adverse effects

V Rajagopalan, Y Zhang, K Ojamaa, Y Chen… - PLoS …, 2016 - journals.plos.org
Background A large body of evidence suggests that thyroid hormones (THs) are beneficial
for the treatment of cardiovascular disorders. We have shown that 3 days of triiodo-L …

Modified low-dose triiodo-L-thyronine therapy safely improves function following myocardial ischemia-reperfusion injury

V Rajagopalan, Y Zhang, C Pol, C Costello… - Frontiers in …, 2017 - frontiersin.org
Background: We have shown that thyroid hormones (THs) are cardioprotective and can be
potentially used as safe therapeutic agents for diabetic cardiomyopathy and permanent …

Thyroid hormone mediates cardioprotection against postinfarction remodeling and dysfunction through the IGF-1/PI3K/AKT signaling pathway

B Zeng, X Liao, L Liu, C Zhang, H Ruan, B Yang - Life sciences, 2021 - Elsevier
Aims Severe cardiovascular diseases, such as myocardial infarction or heart failure, can
alter thyroid hormone (TH) secretion and peripheral conversion, leading to low …

Effects of acute triiodothyronine treatment in patients with anterior myocardial infarction undergoing primary angioplasty: evidence from a pilot randomized clinical trial …

CI Pantos, AG Trikas, EG Pissimisis, KP Grigoriou… - Thyroid, 2022 - liebertpub.com
Background: Thyroid hormone has a differential action on healthy and ischemic heart.
Triiodothyronine (T3) administration improved postischemic cardiac function while it limited …

Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion

MA Hassan Talukder, F Yang… - American Journal …, 2011 - journals.physiology.org
There is emerging evidence that treatment with thyroid hormone (TH) can improve
postischemic cardiac function. 3, 5-Diiodothyropropionic acid (DITPA), a TH analog, has …

Comparison of therapeutic triiodothyronine versus metoprolol in the treatment of myocardial infarction in rats

K Zhang, YD Tang, Y Zhang, K Ojamaa, Y Li, AS Saini… - Thyroid, 2018 - liebertpub.com
Background: Beta blockers are standard therapy for myocardial infarction (MI). Preclinical
studies have shown efficacy and safety of thyroid hormone (TH) treatment of cardiovascular …

Physiological Replacement of T3 Improves Left Ventricular Function in an Animal Model of Myocardial Infarction-Induced Congestive Heart Failure

KK Henderson, S Danzi, JT Paul, G Leya… - Circulation: Heart …, 2009 - Am Heart Assoc
Background—Patients with congestive heart failure (CHF) often have low serum
triiodothyronine (T3) concentrations. In a rodent model of myocardial infarction-induced CHF …

Facilitated recovery of cardiac performance by triiodothyronine following a transient ischemic insult

Y Yokoyama, D Novitzky, MT Deal, TR Snow - Cardiology, 1992 - karger.com
Reperfusion following a transient ischemic insult has been shown to result in a delayed
recovery of myocardial function. A reduction in plasma triiodothyronine (T3) has been …

In vivo selective expression of thyroid hormone receptor α1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice

J Suarez, H Wang, BT Scott, H Ling… - American Journal …, 2014 - journals.physiology.org
Ischemic heart disease (IHD) is the single most common cause of death. New approaches to
enhance myocardial perfusion are needed to improve outcomes for patients with IHD …

Translating thyroid hormone effects into clinical practice: the relevance of thyroid hormone receptor α1 in cardiac repair

C Pantos, I Mourouzis - Heart failure reviews, 2015 - Springer
Thyroid hormone (TH) appears to have a critical role in cardiac repair after injury beyond its
role in development and metabolism homeostasis. This unique action is due to the fact that …