Parthenolide, an NF-κB inhibitor ameliorates diabetes-induced behavioural deficit, neurotransmitter imbalance and neuroinflammation in type 2 diabetes rat model
Diabetes is associated with behavioural and neurochemical alterations. In this manuscript,
we are reporting the beneficial effects of parthenolide, an NF-κB inhibitor on behavioural …
we are reporting the beneficial effects of parthenolide, an NF-κB inhibitor on behavioural …
Suppression of NF-κβ signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits
OBJECTIVE: The etiology of diabetes associated cognitive decline is multifactorial and
involves insulin receptor down regulation, neuronal apoptosis and glutamatergic …
involves insulin receptor down regulation, neuronal apoptosis and glutamatergic …
The novel adamantane derivatives as potential mediators of inflammation and neural plasticity in diabetes mice with cognitive impairment
I Piątkowska-Chmiel, M Gawrońska-Grzywacz… - Scientific Reports, 2022 - nature.com
Diabetes is a chronic disease leading to memory difficulties and deterioration of learning
abilities. The previous studies showed that modulation of inflammatory pathways in the …
abilities. The previous studies showed that modulation of inflammatory pathways in the …
Prophylactic use of troxerutin can delay the development of diabetic cognitive dysfunction and improve the expression of Nrf2 in the hippocampus on STZ diabetic rats
S Zhang, L Yuan, L Zhang, C Li, J Li - Behavioural neurology, 2018 - Wiley Online Library
Background. With the change in lifestyle and the aging population, the incidence of cognitive
dysfunction in diabetes mellitus is rising sharply. Oxidative stress is an important mechanism …
dysfunction in diabetes mellitus is rising sharply. Oxidative stress is an important mechanism …
Neuroprotective effect of epalrestat mediated through oxidative stress markers, cytokines and TAU protein levels in diabetic rats
S Jaiswal, S Mishra, SS Torgal, S Shengule - Life sciences, 2018 - Elsevier
Aims Type-2 diabetes mellitus (DM) is associated with cognitive impairment. Increasing
evidence establishes that neuro-inflammatory and oxidative stress condition plays a main …
evidence establishes that neuro-inflammatory and oxidative stress condition plays a main …
NF-κB inhibition resolves cognitive deficits in experimental type 2 diabetes mellitus through CREB and glutamate/GABA neurotransmitters pathway
A Kumar Datusalia… - Current neurovascular …, 2016 - ingentaconnect.com
Diabetes is associated with deficits in memory and cognitive functions and sustained
inflammation. Recently, involvement of NF-ΚB (nuclear factor kappa-light-chain-enhancer of …
inflammation. Recently, involvement of NF-ΚB (nuclear factor kappa-light-chain-enhancer of …
The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway
S Liu, M Zheng, Y Li, L He, T Chen - Psychopharmacology, 2020 - Springer
The purpose of the present study was to elucidate the pharmacological effects of Geniposide
(GEN) on high diet fed and streptozotocin (STZ)-caused diabetic cognitive impairment. The …
(GEN) on high diet fed and streptozotocin (STZ)-caused diabetic cognitive impairment. The …
Menthol confers neuroprotection through Nrf2/ARE pathway in diabetic encephalopathy
Background: Chronic, long-standing hyperglycemia in diabetes results in diabetic
encephalopathy (DE). It is hallmarked by cognitive dysfunction accelerated by …
encephalopathy (DE). It is hallmarked by cognitive dysfunction accelerated by …
The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction
JPD Tientcheu, FT Ngueguim, RK Gounoue… - Metabolic Brain …, 2023 - Springer
Diabetes-associated cognitive dysfunction is linked to chronic hyperglycemia, oxidative
stress, inflammation, cholinergic dysfunction, and neuronal degeneration. We investigated …
stress, inflammation, cholinergic dysfunction, and neuronal degeneration. We investigated …
Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway
X Zhu, YM Zhang, MY Zhang, YJ Chen, YW Liu - Metabolic Brain Disease, 2021 - Springer
Diabetes-associated affective disorders are of wide concern, and oxidative stress plays a
vital role in the pathological process. This study was to investigate the cerebroprotective …
vital role in the pathological process. This study was to investigate the cerebroprotective …