Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer, and often
derives from pre-existing well-differentiated tumors. Despite a relatively low prevalence, it …

Thyroid malignancies are the most common type of endocrine tumors. Of the various
histologic subtypes, anaplastic thyroid carcinoma (ATC) represents a subset of all cases but …

Rapidly proliferating and neoplastically transformed cells generate the energy required to
support rapid cell division by increasing glycolysis and decreasing flux through the oxidative …

Differentiated thyroid cancers (DTCs) are primarily initiated by mutations that activate the
MAPK signaling cascade, typically at BRAF or RAS oncoproteins. DTCs can evolve to more …

Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are
aggressive thyroid tumors associated with a high mortality rate of 38–57% and almost 100 …

Background: Anaplastic thyroid carcinomas (ATCs) are among the most lethal malignancies,
for which there is no effective treatment. Objective: In the present study, we aimed to …

Context Anaplastic thyroid cancer (ATC) is a rare, aggressive, and deadly disease. Robust
preclinical thyroid cancer models are needed to adequately develop and study novel …

Anaplastic thyroid cancer (ATC) represents one of the most lethal human cancers and
although this tumor type is rare, ATC accounts for the majority of deaths from thyroid cancer …

Thyroid tumors arising from the follicular cells often harbor mutations leading to the
constitutive activation of the PI3K and Ras signaling cascades. However, it is still unclear …

While papillary thyroid cancer (PTC) has largely favorable prognosis, anaplastic thyroid
cancer (ATC) is a rare but extremely aggressive malignancy with grim clinical outcome …