Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in rats

M Xue, Z Jiang, T Wu, J Li, L Zhang, Y Zhao, X Li… - Phytomedicine, 2012 - Elsevier
Tripterygium wilfordii Hook f.(TWHF) has been demonstrated to have anti-inflammatory,
immunosuppressive effects and its clinical use was restricted to some extent due to some …

Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in rats

M Xue, Y Zhao, X Li, Z Jiang, L Zhang, S Liu… - European journal of …, 2012 - Elsevier
The traditional Chinese medicine Tripterygium wilfordii Hook F (TWHF) is used clinically to
treat some autoimmune and inflammatory disorders including rheumatoid arthritis, systemic …

The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle

Z Mei, X Li, Q Wu, S Hu, X Yang - Pharmacological research, 2005 - Elsevier
Triptolide (TP) has been shown to have anti-inflammatory, immunosuppressive, anti-fertility
and anti-neoplastic activity. However, its clinical use was restricted to some extent due to its …

β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway

F Zhang, Z Liu, X He, Z Li, B Shi, F Cai - Drug delivery, 2020 - Taylor & Francis
Rheumatoid arthritis (RA), autoimmune disease that is categorized via chronic inflammation
manifestation, obesity, cardiovascular risk and even enhanced the mortality and affect the …

Ultrasound guided intra-articular injection of triptolide-loaded solid lipid nanoparticle for treatment of antigen-induced arthritis in rabbits

S Li, L Su, G Lv, W Luo, Y Kang - Frontiers in Pharmacology, 2022 - frontiersin.org
Objective: To evaluate the efficacy of ultrasound-guided intra-articular injection of triptolide-
loaded solid lipid nanoparticle (TP-SLN) for treatment of antigen-induced arthritis (AIA) in …

Evaluation of the efficacy and safety of different Tripterygium preparations on collagen-induced arthritis in rats

X Zhu, J Zhang, R Huo, J Lin, Z Zhou, Y Sun… - Journal of …, 2014 - Elsevier
Abstract Ethnopharmacological relevance Tripterygium preparations (TPs), a traditional
Chinese Medicines extracted from Tripterygium wilfordii Hook f., are widely used for …

Anti-inflammatory effects of triptolide loaded poly (D, L-lactic acid) nanoparticles on adjuvant-induced arthritis in rats

M Liu, J Dong, Y Yang, X Yang, H Xu - Journal of ethnopharmacology, 2005 - Elsevier
Triptolide (TP), which has potent immunosuppressive effects, anti-inflammatory and severe
toxicity on digestive, urogenital, blood circulatory system, was used as a model drug in this …

Triptolide loaded solid lipid nanoparticle hydrogel for topical application

Z Mei, Q Wu, S Hu, X Lib, X Yang - Drug development and …, 2005 - Taylor & Francis
Triptolide (TP) has been shown to have anti-inflammatory, antifertility, antineoplastic, and
immunosuppressive activity. However, its clinical usage is limited to some extent due to its …

Tripterygium wilfordii glycosides ameliorates collagen-induced arthritis and aberrant lipid metabolism in rats

Y Zhu, L Zhang, X Zhang, D Wu, L Chen… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, and the
dysregulation of lipid metabolism has been found to play an important role in the …

[HTML][HTML] Eudragit-coated chitosan-tripterygium glycoside conjugate microspheres alleviate DSS-induced experimental colitis by inhibiting the TLR4/NF-κB signaling …

G Xue, H Xiong, S Wang, Y Fu, Y Xie - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Objective Tripterygium glycoside (TG) is a fat-soluble extract of Tripterygium wilfordii, with
anti-inflammatory properties associated with TLR signaling pathways. This study constructed …