Spatial memory deficit and emotional abnormality in OLETF rats

XL Li, S Aou, T Hori, Y Oomura - Physiology & behavior, 2002 - Elsevier
Cholecystokinin (CCK) is deeply involved in the control of learning and emotional behaviors.
The authors characterize the behavioral properties of Otsuka Long Evans Tokushima Fatty …

Spatial memory impairment in OLETF rats without cholecystokinin–a receptor

H Matsushita, J Akiyoshi, K Kai, N Ishii, K Kodama… - Neuropeptides, 2003 - Elsevier
Cholecystokinin (CCK) is one of the most abundant neurotransmitter peptides in the brain.
As Otsuka Long-Evans Tokushima Fatty (OLETF) rats lack CCK-A receptor because of a …

Impaired learning and memory in OLETF rats without cholecystokinin (CCK)-A receptor

S Nomoto, M Miyake, M Ohta, A Funakoshi… - Physiology & …, 1999 - Elsevier
Cholecystokinin (CCK) is one of the most abundant neurotransmitter peptides in the brain.
As OLETF rats lack CCK-A receptor because of a genetic abnormality, we examined …

Increased anxiety behavior in OLETF rats without cholecystokinin-A receptor

Y Yamamoto, J Akiyoshi, A Kiyota, S Katsuragi… - Brain research …, 2000 - Elsevier
Cholecystokinin (CCK) may have a role in the mediation of human panic disorder and
anxiogenic (anxiolytic)-like activity in an animal model of anxiety. Otsuka Long Evans …

Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats

S Kobayashi, M Ohta, K Miyasaka, A Funakoshi - Neuroscience letters, 1996 - Elsevier
We recently found a specific strain of rats (Otsuka Long Evans Tokushima Fatty; OLETF rats)
lacking cholecystokinin (CCK)-A receptor because of a genetic abnormality. Since CCK is …

Lack of satiety effect of cholecystokinin (CCK) in a new rat model not expressing the CCK-A receptor gene

K Miyasaka, S Kanai, M Ohta, T Kawanami, A Kono… - Neuroscience …, 1994 - Elsevier
This work expands recent observations that Otsuka Long-Evans Tokushima Fatty (OLETF)
rats show little or no pancreatic expression of the cholecystokinin (CCK)-A receptor gene …

Involvement of brain endogenous cholecystokinin in stress-induced impairment of spatial recognition memory

V Dauge, M Pophillat, D Crete, S Melik-Parsadaniantz… - Neuroscience, 2003 - Elsevier
The central fragment of cholecystokinin, CCK8, plays a critical role in stress-related changes
in behavior and memory. Therefore, we investigated whether the endogenous …

Cholecystokinin receptors and memory: a radial maze study

J Harro, L Oreland - Pharmacology Biochemistry and Behavior, 1993 - Elsevier
CCK receptor agonists and antagonists have repeatedly been demonstrated to improve and
impair, respectively, learning and memory functions. However, all studies to date have …

Effects of anti-CCK-8 antiserum on acquisition and retrieval by mice in an appetitive task

H Meziane, C Devigne, G Tramu, B Soumireu-Mourat - Peptides, 1993 - Elsevier
Endogenous cholecystokinin (CCK) was blocked in the posterior cingulate cortex of BALB/c
mice using a local injection of anti-CCK-8 antiserum, and memory effects were tested using …

Cholecystokinin-2 (CCK2) receptor-mediated anxiety-like behaviors in rats

H Wang, PTH Wong, J Spiess, YZ Zhu - Neuroscience & Biobehavioral …, 2005 - Elsevier
Cholecystokinin (CCK) is a neurotransmitter in the brain closely related to anxiety. Of the two
CCK receptor subtypes, CCK2 receptors are most implicated in the control of anxiety-related …