Age-related cognitive decline has been linked to a diverse set of neurobiological
mechanisms, including bidirectional changes in proteins critical for neuron function …

Mitochondrial dysfunction and cognitive impairment are common symptoms in many
neurologic and psychiatric disorders, as well as nonpathological aging. Ketones have been …

Energy dense “Western” diets (WD) are known to cause obesity as well as learning and
memory impairments, blood–brain barrier damage, and psychological disturbances …

Introduction Alzheimer's disease (AD) is the most common neurodegenerative disorder that
causes dementia and affects millions of people worldwide. Although it has devastating …

Nutritional ketosis is induced by high fat/low carbohydrate dietary regimens, which produce
high levels of circulating ketone bodies, shifting metabolism away from glucose utilization …

Dietary manipulations are increasingly viewed as possible approaches to treating
neurodegenerative diseases. Previous studies suggest that Alzheimer's disease (AD) …

Dietary interventions can ameliorate age-related neurological decline. Decades of research
of in vitro studies, animal models, and clinical trials support their ability and efficacy to …

There is currently no established therapy to treat or prevent Alzheimer's disease. The
ketogenic diet supplies an alternative cerebral metabolic fuel, with potential neuroprotective …

We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer's
disease (AD) that requires closer attention in the development of AD therapeutics. Our …

Rodents that are insulin resistant and obese as the result of genetic factors, overeating
and/or a sedentary lifestyle, exhibit cognitive deficits that worsen with advancing age …