The phase separation occurring in a system of mutually interacting proteins that can bind on
specific sites of a chromatin fiber is investigated here. This is achieved by means of …

Protein-mediated interactions are ubiquitous in the cellular environment, and particularly in
the nucleus, where they are responsible for the structuring of chromatin. We show through …

In the cell nucleus, chromosomes have a complex spatial organization, spanning several
length scales, which serves vital functional purposes. It is unknown, however, how their …

Within cell nuclei, several biophysical processes occur in order to allow the correct activities
of the genome such as transcription and gene regulation. To quantitatively investigate such …

We present a theoretical study of the interaction between a protein (diffusing particle) and
chromatin (polymer chain). Each monomer is a trap where a particle can transiently bind. We …

Within the nucleus of each cell lies DNA—an unfathomably long, twisted, and intricately
coiled molecule—segments of which make up the genes that provide the instructions that a …

Multi-component phase separation is emerging as a key mechanism for the formation of
biological condensates that play essential roles in signal sensing and transcriptional …

We perform simulations of a system containing simple model proteins and a polymer
representing chromatin. We study the interplay between protein-protein and protein …

Phase-separated multi-molecular assemblies provide a general regulatory mechanism to
compartmentalize biochemical reactions within cells. We propose that a phase separation …

The packaging of DNA in chromosomes presents obstacles to the action of gene regulatory
proteins and polymerases on their natural chromatin substrates. We critically assess …