Plasmodium falciparum (Pf) is a unicellular parasite and the major causative agent of human
malaria. The sporozoite form of the parasite is transferred from mosquitos to humans and …

Malaria remains a global health burden, inflicting millions of people worldwide. Both CD4+ T
cell-and humoral-mediated immunity are crucial to help control parasites in vivo. The …

Protective immunity generated following malaria infection may be comprised of Ab or T cells
against malaria Ag of different stages; however, the short‐lived immunity that is observed …

Malaria is one of the most important infectious diseases in the world. It is estimated that 2.1
billion people live in areas of the world where malaria is transmitted and that there are 100 …

Transgenic (Tg) mice carrying a T‐cell receptor (TCR) specific for a CD8+ T‐cell epitope
expressed in pre‐erythrocytic stages of Plasmodium yoelii has proven to be a valuable tool …

CD4+ helper T cells are critical orchestrators of immune responses to infection and
vaccination. During primary responses, naïve CD8+ T cells may need “CD4 help” for optimal …

Exposure to blood-stage malaria infection is often persistent, leading to generation of CD4
effector and effector memory T cells that contribute to protection. We showed previously that …

Plasmodium falciparum malaria causes 500 million clinical cases with approximately one
million deaths each year. After many years of exposure, individuals living in endemic areas …

Whole sporozoite vaccines represent one of the most promising strategies to induce
protection against malaria. However, the development of efficient vaccination protocols still …

It is now generally accepted that peripheral blood of humans not exposed previously to
malaria contains T cells which proliferate vigorously in response to malaria parasites and …