Simple Summary The immunosuppressive microenvironment is closely related to the poor
prognosis of patients with PDAC. Tfh cells play an anti-tumor function in various malignant …

Despite continued improvement in conventional therapy, pancreatic cancer continues to be
one of the deadliest tumors worldwide with abysmal 5-year survival rate. New …

Cancer immunotherapy targeting immune checkpoints has exhibited promising clinical
outcomes in many cancers, but it offers only limited benefits for pancreatic cancer (PC) …

Background T follicular helper cells (Tfh) are essential to shape B cell response during
germinal center formation. Tfh accumulation has been reported in various human cancers …

Background Human pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune
checkpoint inhibitor (ICPi). While the mechanism is not completely clear, it has been …

Background and Aims CD4+ T follicular helper (Tfh) cells, a new subset of immune cells,
have been demonstrated to be involved in the development and prognosis of tumors …

Recent studies have demonstrated that higher expression of follicular helper T cell (Tfh)-
associated genes is associated with better prognosis in breast cancer and colorectal cancer …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic
reaction driven by pancreatic stellate cells (PSCs) that contributes to tumor progression …

Simple Summary In light of the majority of pancreatic cancer patients not responding to
current immune checkpoint blockade, alternative immunotherapeutic targets need to be …

Pancreatic ductal adenocarcinoma (PDAC) is the major type of pancreatic malignancy with
very poor prognosis. Despite the promising results of immune checkpoint inhibitors (ICIs) in …