Spirodienone derivatives have unique structural characteristics. Its spiroatoms are
quaternary carbons that act as bridges between dienone and four, five, six and even seven …

Background: The spirocyclic compounds have always aroused a great interest because this
motif is present as structural core in a number of natural products and bioactive compounds …

The spiroketal moiety is an important privileged scaffold that occurs extensively in natural
products, drugs, and bioactive molecules. Naturally occurring spiroketals are numerous …

SPIRO COMPOUNDS A comprehensive treatment of the latest research in, and applications
of, spiro compounds Spiro Compounds: Synthesis and Applications combines discussions …

Objective The spirooxindole heterocyclic scaffold is found in many natural products and has
been identified as an important bioactive agent. Background Over the past few decades …

Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system
and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their …

Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

Spirocompounds constitute an important class of organic frameworks enveloping numerous
pharmacological activities, among them, the promising anticancer potential of …

Spirocycles are ring systems in which two rings are fused through a single atom, referred to
as the spiro atom. The ethylene glycol ketal of cyclohexanone is an example of a well-known …

Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in
drug design processes. Significant attention has been directed at obtaining molecules …