Structural and thermodynamic properties of HLA-B27 molecules provide the basis for their
function within the immune system and are probably also central for the understanding of the …

Molecular polymorphism influences the strong association of HLA-B27 with ankylosing
spondylitis through an unknown mechanism. Natural subtypes and site-directed mutants …

Selected HLA-B27 subtypes are associated with spondyloarthropathies, but the underlying
mechanism is not understood. To explain this association in molecular terms, a comparison …

The presentation of short viral peptide antigens by human leukocyte antigen (HLA) class I
molecules on cell surfaces is a key step in the activation of cytotoxic T lymphocytes, which …

The peptide specificity of HLA-B* 1403, an allotype associated with ankylosing spondylitis
(Lopez-Larrea, C., Mijiyawa, M., Gonzalez, S., Fernandez-Morera, JL, Blanco-Gelaz, MA …

The strong association of the human MHC class I allele HLA-B27 with the development of
the chronic inflammatory disease ankylosing spondylitis (AS) is clear and has been known …

HLA‐B27 is the major genetic susceptibility factor for ankylosing spondylitis (AS). However,
its precise role in the pathogenesis of AS still remains unclear, even though its gene has …

HLA-B27 is strongly associated with susceptibility to ankylosing spondylitis and other
spondyloarthropathies. Structural analysis of this antigen has revealed the existence of …

The arthritogenic peptide hypothesis has inspired research aimed at defining the peptide-
presenting properties of HLA-B27 subtypes and their relation to ankylosing spondylitis …

HLA-B27 represents a family of 38 closely related cell surface proteins (encoded by the
alleles HLA-B* 2701-39) called subtypes of HLA-B27, most of which have evolved from the …