Glucose homeostasis depends on regulated insulin secretion from pancreatic β cells, which
acquire their mature phenotype postnatally. The functional maturation of β cells is regulated …

In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as
diabetes treatment. Despite recent progress, efforts to generate physiologically competent β …

Inhibitor of DNA binding (Id) proteins bind to and inhibit the function of basic helix-loop-helix
(bHLH) transcription factors including those that regulate pancreatic development …

The interplay between pancreatic epithelium and the surrounding microenvironment is
pivotal for pancreas formation and differentiation as well as adult organ homeostasis. The …

Pathological or functional loss of pancreatic beta cells is the cause of diabetes.
Understanding how signaling pathways regulate pancreatic lineage and searching for …

While several transcription factors are known to increase insulin production and secretion,
their therapeutic potential for treatment of type 2 diabetes remains unrealized. In this issue …

As one of the key nutrient sensors, insulin signaling plays an important role in integrating
environmental energy cues with organism growth. In adult organisms, relative insufficiency …

Despite advances in the differentiation of insulin-producing cells from human embryonic
stem cells, the generation of mature functional β cells in vitro has remained elusive. To …

An unlimited source of human pancreatic β cells is in high demand. Even with recent
advances in pancreatic differentiation from human pluripotent stem cells, major hurdles …

In the field of stem cell biology and diabetes, we and others seek to derive mature and
functional human pancreatic β cells for disease modeling and cell replacement therapy …