Androgen receptor (AR) splice variants (AR-Vs) have been implicated in the development
and progression of metastatic prostate cancer. AR-Vs are truncated isoforms of the AR, a …

The role of dysregulation of mRNA alternative splicing (AS) in the development and
progression of solid tumors remains to be defined. Here we describe the first comprehensive …

Simple Summary Androgen receptor splice variants (AR-Vs) play an important role in
prostate cancer progression, especially as a putative resistance mechanism against AR …

Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple
mechanisms, one of which is to express constitutively active androgen receptor (AR) splice …

Background Dysregulation of splicing variants (SVs) expression has recently emerged as a
novel cancer hallmark. Although the generation of aberrant SVs (eg AR-v7/sst5TMD4/etc.) is …

The ability for cells to harness alternative splicing enables them to diversify their proteome in
order to carry out complex biological functions and adapt to external and internal stimuli. The …

Although inhibition of the androgen–androgen receptor (AR) axis effectively represses the
growth of prostate cancer, most of all cases eventually become castration-resistant prostate …

Purpose: Mechanisms mediating androgen receptor (AR) reactivation in prostate cancer that
progresses after castration (castration-resistant prostate cancer; CRPC) and subsequent …

Prostate cancer is the second leading cause of cancer-related death in American men.
Although most prostate cancers are initially androgen-dependent and respond to androgen …

Therapeutic interventions for advanced prostate cancer (PCa) center on inhibiting androgen
receptor (AR) and downstream signaling pathways. Resistance to androgen deprivation …