Cisplatin is one of the most potent and widely used chemotherapeutic agent in the treatment
of several solid tumors, despite the high toxicity and the frequent relapse of patients due to …

Cisplatin is a chemotherapy drug commonly used in cancer treatment. Tumour cells are
more sensitive to cisplatin than normal cells. Cisplatin exerts an antitumour effect by …

Cisplatin (cis-diamminedichloroplatinum (II)) is the oldest known chemotherapeutic agent.
Since the identification of its anti-tumour activity, it earned a remarkable place as a treatment …

Resistance to therapeutic agents, either intrinsic or acquired, is currently a major problem in
the treatment of cancers and occurs in virtually every type of anti-cancer therapy. Therefore …

Background Cisplatin (CDDP) is a mainstay treatment for advanced head and neck
squamous cell carcinomas (HNSCC) despite a high frequency of innate and acquired …

Cisplatin and carboplatin are among the most active and widely used cytotoxic anticancer
drugs. However, the acquisition or presence of resistance significantly undermines the …

Cisplatin is the most widely used chemotherapeutic agent, and resistance of neoplastic cells
against this cytoxicant poses a major problem in clinical oncology. Here, we explored …

Although cisplatin has been a pivotal chemotherapy drug in treating patients with various
types of cancer for decades, drug resistance has been a major clinical impediment. In …

The development of drug resistance in tumors is a major obstacle to effective cancer
chemotherapy and represents one of the most significant complications to improving long …

Carboplatin is a derivative of cisplatin; it has a similar mechanism of action, but differs in
terms of structure and toxicity. It was approved by the FDA in the 1980s and since then it has …