An observational and Mendelian randomisation study on iron status and sepsis
Iron deficiency is associated with a substantial burden of morbidity. However,
supplementation of iron has been linked to increased rates of serious infection in …
supplementation of iron has been linked to increased rates of serious infection in …
Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach
G Butler-Laporte, Y Farjoun, Y Chen… - International Journal …, 2023 - academic.oup.com
Objectives Increased iron stores have been associated with elevated risks of different
infectious diseases, suggesting that iron supplementation may increase the risk of infections …
infectious diseases, suggesting that iron supplementation may increase the risk of infections …
Causal effects of genetically predicted iron status on sepsis: A two-sample bidirectional Mendelian randomization study
Y Hu, X Cheng, H Mao, X Chen, Y Cui, Z Qiu - Frontiers in Nutrition, 2021 - frontiersin.org
Background/Aim: Several observational studies showed a significant association between
elevated iron status biomarkers levels and sepsis with the unclear direction of causality. A …
elevated iron status biomarkers levels and sepsis with the unclear direction of causality. A …
Does moderate iron deficiency protect against childhood illness? A test of the optimal iron hypothesis in Tanzania
Objectives To test the hypothesis that moderate iron deficiency among children is associated
with lower likelihood of infection. Materials and Methods We use data from a population …
with lower likelihood of infection. Materials and Methods We use data from a population …
The importance of iron status for young children in low-and middle-income countries: a narrative review
AE Armitage, D Moretti - Pharmaceuticals, 2019 - mdpi.com
Early childhood is characterised by high physiological iron demand to support processes
including blood volume expansion, brain development and tissue growth. Iron is also …
including blood volume expansion, brain development and tissue growth. Iron is also …
Effect of iron supplementation on incidence of infectious illness in children: systematic review
T Gera, HPS Sachdev - Bmj, 2002 - bmj.com
Objective: To evaluate the effect of iron supplementation on the incidence of infections in
children. Design: Systematic review of randomised controlled trials. Data sources: 28 …
children. Design: Systematic review of randomised controlled trials. Data sources: 28 …
Evaluation of iron deficiency as a nutritional adaptation to infectious disease: an evolutionary medicine perspective
K Wander, B Shell‐Duncan… - American Journal of …, 2009 - Wiley Online Library
An evolutionary perspective suggests that iron deficiency may have opposing effects on
infectious disease risk, decreasing susceptibility by restricting iron availability to pathogens …
infectious disease risk, decreasing susceptibility by restricting iron availability to pathogens …
Lower incidence of respiratory infections among iron-deficient children in Kilimanjaro, Tanzania
K Wander, B Shell-Duncan… - Evolution, medicine, and …, 2017 - academic.oup.com
Objective: We posited a trade-off in iron nutrition, with iron deficiency decreasing risk for
infection by depriving infectious agents of iron while increasing risk for infection by …
infection by depriving infectious agents of iron while increasing risk for infection by …
Influence of iron status on risk of maternal or neonatal infection and on neonatal mortality with an emphasis on developing countries
L Brabin, BJ Brabin, S Gies - Nutrition reviews, 2013 - academic.oup.com
Infection is a major cause of neonatal death in developing countries. This review
investigates whether host iron status affects the risk of maternal and/or neonatal infection …
investigates whether host iron status affects the risk of maternal and/or neonatal infection …
Anaemia, iron deficiency and susceptibility to infection in children in sub‐Saharan Africa, guideline dilemmas
FAM Jonker, E Te Poel, I Bates… - British Journal of …, 2017 - Wiley Online Library
Globally, anaemia, iron deficiency and infections are responsible for a majority of the
morbidity and mortality that occurs among children. As iron is essential for erythropoiesis …
morbidity and mortality that occurs among children. As iron is essential for erythropoiesis …