An observational and Mendelian randomisation study on iron status and sepsis

F Hamilton, R Mitchell, H Ahmed, P Ghazal… - Scientific Reports, 2023 - nature.com
Iron deficiency is associated with a substantial burden of morbidity. However,
supplementation of iron has been linked to increased rates of serious infection in …

Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach

G Butler-Laporte, Y Farjoun, Y Chen… - International Journal …, 2023 - academic.oup.com
Objectives Increased iron stores have been associated with elevated risks of different
infectious diseases, suggesting that iron supplementation may increase the risk of infections …

Causal effects of genetically predicted iron status on sepsis: A two-sample bidirectional Mendelian randomization study

Y Hu, X Cheng, H Mao, X Chen, Y Cui, Z Qiu - Frontiers in Nutrition, 2021 - frontiersin.org
Background/Aim: Several observational studies showed a significant association between
elevated iron status biomarkers levels and sepsis with the unclear direction of causality. A …

Does moderate iron deficiency protect against childhood illness? A test of the optimal iron hypothesis in Tanzania

C Hadley, JA DeCaro - American journal of physical …, 2015 - Wiley Online Library
Objectives To test the hypothesis that moderate iron deficiency among children is associated
with lower likelihood of infection. Materials and Methods We use data from a population …

The importance of iron status for young children in low-and middle-income countries: a narrative review

AE Armitage, D Moretti - Pharmaceuticals, 2019 - mdpi.com
Early childhood is characterised by high physiological iron demand to support processes
including blood volume expansion, brain development and tissue growth. Iron is also …

Effect of iron supplementation on incidence of infectious illness in children: systematic review

T Gera, HPS Sachdev - Bmj, 2002 - bmj.com
Objective: To evaluate the effect of iron supplementation on the incidence of infections in
children. Design: Systematic review of randomised controlled trials. Data sources: 28 …

Evaluation of iron deficiency as a nutritional adaptation to infectious disease: an evolutionary medicine perspective

K Wander, B Shell‐Duncan… - American Journal of …, 2009 - Wiley Online Library
An evolutionary perspective suggests that iron deficiency may have opposing effects on
infectious disease risk, decreasing susceptibility by restricting iron availability to pathogens …

Lower incidence of respiratory infections among iron-deficient children in Kilimanjaro, Tanzania

K Wander, B Shell-Duncan… - Evolution, medicine, and …, 2017 - academic.oup.com
Objective: We posited a trade-off in iron nutrition, with iron deficiency decreasing risk for
infection by depriving infectious agents of iron while increasing risk for infection by …

Influence of iron status on risk of maternal or neonatal infection and on neonatal mortality with an emphasis on developing countries

L Brabin, BJ Brabin, S Gies - Nutrition reviews, 2013 - academic.oup.com
Infection is a major cause of neonatal death in developing countries. This review
investigates whether host iron status affects the risk of maternal and/or neonatal infection …

Anaemia, iron deficiency and susceptibility to infection in children in sub‐Saharan Africa, guideline dilemmas

FAM Jonker, E Te Poel, I Bates… - British Journal of …, 2017 - Wiley Online Library
Globally, anaemia, iron deficiency and infections are responsible for a majority of the
morbidity and mortality that occurs among children. As iron is essential for erythropoiesis …