(57) ABSTRACT A mucosal vaccine for Neisseria based on native outer membrane vesicles
(NOMV) prepared from genetically engineered vaccine strain and unexposed to detergents …

A composition is prepared from a mixture of different vesicles, such as outer membrane
vesicles (OMVs) and vaccines are based thereon. Another composition comprises in a …

The present invention discloses a Gram negative bacterium in which the expression of a
protein involved in LPS transport to the outer membrane is functionally downregulated Such …

US6916478B2 - Vaccines and pharmaceutical compositions using membrane vesicles of
microorganisms, and methods for preparing same - Google Patents US6916478B2 …

(57) ABSTRACT A composition comprising (a) Neisseria meningitidis sero group B outer
membrane vesicles (OMVs), and (b) an immu nogenic component selected from …

The present invention discloses a Gram negative bacterium in which the expression of a
protein involved in LPS transport to the outer membrane is functionally downregulated such …

US7118757B1 - Meningococcal class 1 outer-membrane protein vaccine - Google Patents
US7118757B1 - Meningococcal class 1 outer-membrane protein vaccine - Google Patents …

The present invention generally provides methods and com positions for eliciting an immune
response against Neisseria spp. bacteria in a subject, using vesicle vaccines made from …

Described herein is a method for removing toxic lipooli gosaccharide (LOS) from outer
membranes of Gram negative cocci, Such as Neisseria meningitidis. LOS depleted outer …

(57) ABSTRACT A composition is provided comprising N. meningitidis outer membrane
vesicles, wherein Said outer membrane Vesicles are enriched with at least one antigenic …