Background Many patients with nasopharyngeal carcinoma (NPC) face poor prognosis. Due
to its hidden anatomical location, the tumor is usually diagnosed quite late, and despite …

Simple Summary Nasopharyngeal carcinoma (NPC) is a cancer that is frequently associated
with Epstein–Barr virus (EBV) infection, and this virus is thought to play a role in NPC …

Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy without efficient
chemotherapeutic agents for it. In our current study, we demonstrated the cytotoxicity effects …

Patients with glioblastoma multiforme (GBM), a malignant primary brain tumor, inevitably
develop resistance to standard-of-care chemotherapy, temozolomide. This study explores …

Background NEO212 is a novel small-molecule anticancer agent that was generated by
covalent conjugation of the natural monoterpene perillyl alcohol (POH) to the alkylating …

Advanced nasopharyngeal carcinoma (NPC) has a poor prognosis because of the lack of an
effective treatment. Here we explored the efficiency and the molecular mechanisms of …

The DNA repair enzyme O6-methylguanin-DNA-methltransferase (MGMT) is able to remove
products of alkylating agent such as O6-meG and emerges as a central determinant of …

Temozolomide (TMZ) is a methylating agent with promising antitumour activity against
primary or secondary brain tumours. Through the generation of a reactive intermediate, TMZ …

Advanced nasopharyngeal carcinoma (NPC) has a poor prognosis, with an unfavorable
response to palliative chemotherapy. Unfortunately, there are few effective therapeutic …

Temozolomide (TMZ) exerts its cytotoxic effects by methylating guanine in DNA, resulting in
a mismatch with thymine. We studied possible enhancement of the cytotoxic activity of …