Mating differentiation in Cryptococcus neoformans is negatively regulated by the Crk1 protein kinase

KH Liu, WC Shen - Fungal Genetics and Biology, 2011 - Elsevier
Cryptococcus neoformans is a heterothallic basidiomycete that grows vegetatively as yeast
and filamentous hyphae are produced in the sexual state. Previous studies have shown that …

Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in Cryptococcus neoformans

YK Lu, KH Sun, WC Shen - Molecular microbiology, 2005 - Wiley Online Library
Cryptococcus neoformans is a heterothallic basidiomycetous yeast that primarily infects
immunocompromised individuals. Dikaryotic hyphae resulting from the fusion of the MATa …

PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex

C Fu, J Heitman - PLoS Genetics, 2017 - journals.plos.org
Sexual reproduction is critical for successful evolution of eukaryotic organisms in adaptation
to changing environments. In the opportunistic human fungal pathogens, the Cryptococcus …

Uniqueness of the mating system in Cryptococcus neoformans

CM McClelland, YC Chang, A Varma… - Trends in …, 2004 - cell.com
Although the mating system of Cryptococcus neoformans shares many physiological and
genetic characteristics with other fungi, there are an increasing number of features that make …

A screening for suppressor mutants reveals components involved in the blue light-inhibited sexual filamentation in Cryptococcus neoformans

YL Yeh, YS Lin, BJ Su, WC Shen - Fungal Genetics and Biology, 2009 - Elsevier
Blue light regulates diverse physiological and developmental processes in fungi. Our prior
studies demonstrated that the evolutionally conserved Cwc1 and Cwc2 proteins mediate the …

PAK Kinases Ste20 and Pak1 Govern Cell Polarity at Different Stages of Mating in Cryptococcus neoformans

CB Nichols, JA Fraser, J Heitman - Molecular biology of the cell, 2004 - Am Soc Cell Biol
Sexual identity and mating are linked to virulence of the fungal pathogen Cryptococcus
neoformans. Cells of the α mating type are more prevalent and can be more virulent than a …

Transcription Factors Mat2 and Znf2 Operate Cellular Circuits Orchestrating Opposite- and Same-Sex Mating in Cryptococcus neoformans

X Lin, JC Jackson, M Feretzaki, C Xue, J Heitman - PLoS genetics, 2010 - journals.plos.org
Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic
transition from a unicellular yeast to multicellular hyphae during opposite sex (mating) and …

Mating-Type-Specific and Nonspecific PAK Kinases Play Shared and Divergent Roles in Cryptococcus neoformans

P Wang, CB Nichols, KB Lengeler, ME Cardenas… - Eukaryotic …, 2002 - Am Soc Microbiol
Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle
involving fusion of haploid MAT α and MAT a cells. Virulence has been linked to the mating …

Signal transduction cascades regulating mating, filamentation, and virulence in Cryptococcus neoformans

P Wang, J Heitman - Current opinion in microbiology, 1999 - Elsevier
Cryptococcus neoformans is a basidiomycetous fungal pathogen that infects the central
nervous system. The organism has a defined sexual cycle involving mating between haploid …

Function of Cryptococcus neoformans KAR7 (SEC66) in Karyogamy during Unisexual and Opposite-Sex Mating

SC Lee, J Heitman - Eukaryotic cell, 2012 - Am Soc Microbiol
The human basidiomycetous fungal pathogen Cryptococcus neoformans serves as a model
fungus to study sexual development and produces infectious propagules, basidiospores, via …