Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif
TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a …

Synthetic oligodeoxynucleotides (ODNs) expressing immunosuppressive TTAGGG motifs
downregulate the production of proinflammatory and Th1 cytokines. The ability of these …

Synthetic oligodeoxynucleotides (ODN) capable of “neutralizing” or “inhibiting” immune
responses have been described. This review will focus on the properties of …

Activation of TLR7 and TLR9 by endogenous RNA-or DNA-containing ligands, respectively,
is thought to contribute to the complicated pathophysiology of systemic lupus erythematosus …

Oligonucleotides with a “CpG” motif trigger a proinflammatory response through activation of
Toll-like receptor 9 (TLR9) and are being studied to exploit these properties for use as …

Short synthetic oligodeoxynucleotides (ODNs) rich in CpG or GpG motifs have been
considered as potential modulators of immunity in clinical settings. In this study, we show …

Endotoxic shock is a life-threatening condition caused by exposure to bacterial LPS. LPS
triggers the release of acute phase, proinflammatory, and Th1 cytokines that facilitate the …

Oligonucleotide-based therapeutics have become a reality, and are set to transform
management of many diseases. Nevertheless, the modulatory activities of these molecules …

To explore the possibility that human mitochondrial genomic DNA‐mimicking
oligodeoxynucleotides could regulate the immune response, a series of mitochondrial DNA …

Our immune defense depends on two specialized armed forces. The innate force acts as an
alarm mechanism that senses changes in the microenvironment through the recognition of …