Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …

Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the
genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN) …

There are 3 major forms of autosomal dominant tubulointerstitial kidney disease (ADTKD):
ADTKD due to UMOD mutations, MUC1 mutations, and mutations in the REN gene …

Rationale & Objective Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a
rare underdiagnosed cause of end-stage renal disease (ESRD). ADTKD is caused by …

Autosomal-dominant tubulo-interstitial kidney disease (ADTKD) encompasses a group of
disorders characterized by renal tubular and interstitial abnormalities, leading to slow …

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized
cause of end-stage kidney disease, primarily due to mutations in UMOD and MUC1. The …

Background Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by
mutations in the UMOD gene (ADTKD-UMOD) is considered rare and often remains …

For decades, ill-defined autosomal dominant renal diseases have been reported, which
originate from tubular cells and lead to tubular atrophy and interstitial fibrosis. These …

Background Autosomal dominant tubulointerstitial kidney disease caused by mucin-1 gene
(MUC1) mutations (ADTKD-MUC1) is characterized by progressive kidney failure. Genetic …

Although the kidney has capacity to repair after mild injury, ongoing or severe damage
results in scarring (fibrosis) and an associated progressive loss of kidney function. However …