Sesterterpenoids are a rare terpene class harboring untapped chemodiversity and
bioactivities. Their structural diversity originates primarily from the scaffold-generating …

Class I terpene synthase (TPS) generates bioactive terpenoids with diverse backbones.
Sesterterpene synthase (sester-TPS, C25), a branch of class I TPSs, was recently identified …

Terpenoids, including aromatic volatile monoterpenoids and sesquiterpenoids, function in
defense against pathogens and herbivores. Phoebe trees are remarkable for their scented …

Heterologous expression of four clade-A bifunctional terpene synthases (BFTSs), giving
di/sesterterpenes with unique polycyclic carbon skeletons such as sesterfisherol, enabled …

Plants produce an array of specialized metabolites with important ecological functions. The
mechanisms underpinning the evolution of new biosynthetic pathways are not well …

Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …

Terpenes are organic compounds and play important roles in plant growth and development
as well as in mediating interactions of plants with the environment. Terpene synthases (TPS …

Sesterterpenoids are a group of terpenoid natural products that are primarily biosynthesized
via cyclization of the C25 linear substrate geranylfarnesyl pyrophosphate (GFPP). Although …

Terpenoids constitute a structurally diverse group of natural products with wide applications
in the pharmaceutical, nutritional, flavor and fragrance industries. Fungi are known to …

Genome mining is a promising method to discover novel secondary metabolites in the
postgenomic era. We applied the Aspergillus oryzae heterologous expression system to …