Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

BJ Tunstall, D Kirson, LJ Zallar, SA McConnell… - PLoS …, 2019 - journals.plos.org
Oxytocin administration has been reported to decrease consumption, withdrawal, and drug-
seeking associated with several drugs of abuse and thus represents a promising …

Targeting the oxytocin system to treat addictive disorders: rationale and progress to date

MR Lee, MCH Rohn, G Tanda, L Leggio - CNS drugs, 2016 - Springer
The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning, and
memory processes. As such, there is increasing interest in oxytocin as a potential treatment …

Oxytocin reduces ethanol self‐administration in mice

CE King, WC Griffin, LN Luderman… - Alcoholism: clinical …, 2017 - Wiley Online Library
Background Excessive ethanol (EtOH) consumption remains an important health concern
and effective treatments are lacking. The central oxytocin system has emerged as a …

Oxytocin reduces alcohol cue-reactivity in alcohol-dependent rats and humans

AC Hansson, A Koopmann, S Uhrig, S Bühler… - …, 2018 - nature.com
Approved pharmacological treatments for alcohol use disorder are limited in their
effectiveness, and new drugs that can easily be translated into the clinic are warranted. One …

Peripheral oxytocin administration reduces ethanol consumption in rats

K MacFadyen, R Loveless, B DeLucca… - Pharmacology …, 2016 - Elsevier
The neuropeptide oxytocin interacts with mesolimbic dopamine neurons to mediate reward
associated with filial behaviors, but also other rewarding behaviors such as eating or taking …

Systemic oxytocin administration alters mesolimbic dopamine release in mice

MK Estes, TG Freels, WT Prater, DB Lester - Neuroscience, 2019 - Elsevier
Growing research indicates oxytocin may be involved in relieving anxiety and attenuating
the rewarding effects of psychostimulants. This study investigated the effects of subchronic …

Oxytocin inhibits ethanol consumption and ethanol‐induced dopamine release in the nucleus accumbens

ST Peters, MT Bowen, K Bohrer, IS McGregor… - Addiction …, 2017 - Wiley Online Library
Alcohol (EtOH) is one of the most widely abused recreational drugs and is arguably the most
harmful. However, current treatment options for alcohol‐use disorders generally have limited …

Effect of alcohol use disorder on oxytocin peptide and receptor mRNA expression in human brain: A post-mortem case-control study

MR Lee, ML Schwandt, V Sankar, P Suchankova… - …, 2017 - Elsevier
Animal and human evidence supports a role for oxytocin in alcohol-seeking behaviors.
There is interest, therefore, in targeting the oxytocin pathway as a new pharmacologic …

Breaking the loop: oxytocin as a potential treatment for drug addiction

IS McGregor, MT Bowen - Hormones and behavior, 2012 - Elsevier
Drug use typically occurs within a social context, and social factors play an important role in
the initiation, maintenance and recovery from addictions. There is now accumulating …

Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in …

DS Carson, GE Hunt, AJ Guastella, L Barber… - Addiction …, 2010 - Wiley Online Library
Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in
the treatment of drug dependence and drug withdrawal. Oxytocin reduces …