Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala
Oxytocin administration has been reported to decrease consumption, withdrawal, and drug-
seeking associated with several drugs of abuse and thus represents a promising …
seeking associated with several drugs of abuse and thus represents a promising …
Targeting the oxytocin system to treat addictive disorders: rationale and progress to date
The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning, and
memory processes. As such, there is increasing interest in oxytocin as a potential treatment …
memory processes. As such, there is increasing interest in oxytocin as a potential treatment …
Oxytocin reduces ethanol self‐administration in mice
CE King, WC Griffin, LN Luderman… - Alcoholism: clinical …, 2017 - Wiley Online Library
Background Excessive ethanol (EtOH) consumption remains an important health concern
and effective treatments are lacking. The central oxytocin system has emerged as a …
and effective treatments are lacking. The central oxytocin system has emerged as a …
Oxytocin reduces alcohol cue-reactivity in alcohol-dependent rats and humans
AC Hansson, A Koopmann, S Uhrig, S Bühler… - …, 2018 - nature.com
Approved pharmacological treatments for alcohol use disorder are limited in their
effectiveness, and new drugs that can easily be translated into the clinic are warranted. One …
effectiveness, and new drugs that can easily be translated into the clinic are warranted. One …
Peripheral oxytocin administration reduces ethanol consumption in rats
K MacFadyen, R Loveless, B DeLucca… - Pharmacology …, 2016 - Elsevier
The neuropeptide oxytocin interacts with mesolimbic dopamine neurons to mediate reward
associated with filial behaviors, but also other rewarding behaviors such as eating or taking …
associated with filial behaviors, but also other rewarding behaviors such as eating or taking …
Systemic oxytocin administration alters mesolimbic dopamine release in mice
Growing research indicates oxytocin may be involved in relieving anxiety and attenuating
the rewarding effects of psychostimulants. This study investigated the effects of subchronic …
the rewarding effects of psychostimulants. This study investigated the effects of subchronic …
Oxytocin inhibits ethanol consumption and ethanol‐induced dopamine release in the nucleus accumbens
Alcohol (EtOH) is one of the most widely abused recreational drugs and is arguably the most
harmful. However, current treatment options for alcohol‐use disorders generally have limited …
harmful. However, current treatment options for alcohol‐use disorders generally have limited …
Effect of alcohol use disorder on oxytocin peptide and receptor mRNA expression in human brain: A post-mortem case-control study
MR Lee, ML Schwandt, V Sankar, P Suchankova… - …, 2017 - Elsevier
Animal and human evidence supports a role for oxytocin in alcohol-seeking behaviors.
There is interest, therefore, in targeting the oxytocin pathway as a new pharmacologic …
There is interest, therefore, in targeting the oxytocin pathway as a new pharmacologic …
Breaking the loop: oxytocin as a potential treatment for drug addiction
IS McGregor, MT Bowen - Hormones and behavior, 2012 - Elsevier
Drug use typically occurs within a social context, and social factors play an important role in
the initiation, maintenance and recovery from addictions. There is now accumulating …
the initiation, maintenance and recovery from addictions. There is now accumulating …
Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in …
Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in
the treatment of drug dependence and drug withdrawal. Oxytocin reduces …
the treatment of drug dependence and drug withdrawal. Oxytocin reduces …
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