The role of nitric oxide, reactive oxygen species, and protein kinase C in oxytocin-induced cardioprotection in ischemic rat heart

M Faghihi, AM Alizadeh, V Khori, M Latifpour… - Peptides, 2012 - Elsevier
Ischemia–reperfusion injury is a common complication of heart disease that is the leading
cause of death worldwide. Here, we plan to elucidate oxytocin cardioprotection effects …

The SAFE pathway is involved in the postconditioning mechanism of oxytocin in isolated rat heart

M Polshekan, V Khori, AM Alizadeh… - Peptides, 2019 - Elsevier
Oxytocin (OT) has a postconditioning effect against the ischemia-reperfusion (I/R) injury.
However, its precise cardioprotection mechanism at the early reperfusion phase remains …

Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusion

M Ondrejcakova, T Ravingerova… - Canadian journal of …, 2009 - cdnsciencepub.com
Among the cardiovascular pathologies, ischemic heart disease is a serious medical problem
that can result in cardiac injury and (or) heart failure. The aim of the present study was to test …

Oxytocin protects rat heart against ischemia–reperfusion injury via pathway involving mitochondrial ATP-dependent potassium channel

AM Alizadeh, M Faghihi, HR Sadeghipour… - Peptides, 2010 - Elsevier
Cardiac preconditioning represents the most potent and consistently reproducible method of
rescuing heart tissue from undergoing irreversible ischemic damage. One of the major goals …

[HTML][HTML] Oxytocin ameliorates ischemia/reperfusion-induced injury by inhibiting mast cell degranulation and inflammation in the rat heart

W Xiong, M Yao, R Zhou, Y Qu, Y Yang, Z Wang… - Biomedicine & …, 2020 - Elsevier
Background Oxytocin (OT) has shown a cardioprotective effect on myocardial
ischemia/reperfusion injury (MIRI). This study aimed to investigate whether the …

Role of atrial natriuretic Peptide in oxytocin induced cardioprotection

F Houshmand, M Faghihi, S Zahediasl - Heart, Lung and Circulation, 2015 - Elsevier
Background The purpose of this study was to determine whether endogenous atrial
natriuretic peptide (ANP) contributes to the protective effect of neurohypophysial hormone …

Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats

F Houshmand, M Faghihi, S Zahediasl - Peptides, 2009 - Elsevier
Oxytocin (OT) is well known for its role in reproduction. However, evidence has emerged
suggesting a role in cardiovascular system. The aim of this study was to investigate the …

Anti-inflammatory effect of oxytocin in rat myocardial infarction

M Jankowski, V Bissonauth, L Gao, M Gangal… - Basic Research in …, 2010 - Springer
While an increasing amount of evidence demonstrates the homeostatic functions of the
cardiac oxytocin (OT) system, less is known about the role of this hormone in the injured …

[HTML][HTML] The role of oxytocin in cardiovascular protection

M Jankowski, TL Broderick, J Gutkowska - Frontiers in psychology, 2020 - frontiersin.org
The beneficial effects of oxytocin on infarct size and functional recovery of the ischemic
reperfused heart are well documented. The mechanisms for this cardioprotection are not …

The administration of oxytocin during early reperfusion, dose-dependently protects the isolated male rat heart against ischemia/reperfusion injury

MA Anvari, A Imani, M Faghihi, SM Karimian… - European journal of …, 2012 - Elsevier
In our previous study, the administration of oxytocin (OT) could precondition the heart
against ischemia/reperfusion injury. In this study, to investigate the cardiac postconditioning …