Lithium is commonly prescribed as a mood stabilizer in a variety of mental health conditions,
yet its molecular mode of action is incompletely understood. Many cellular events associated …

Among the numerous effects of lithium on intracellular targets, its possible action on
mitochondria remains poorly explored. In the experiments with suspension of isolated brain …

The monovalent cation lithium partially exerts its effects by activating neurotrophic and
neuroprotective cellular cascades. Here, we discuss the effects of lithium on oxidative stress …

Mitochondria play vital role in regulating the cellular energetics and metabolism. Further, it is
a signaling hub for cell survival and apoptotic pathways. One of the key determinants that …

Rationale Different lines of evidence suggest that mitochondrial dysfunction may be
implicated in bipolar disorder (BD) pathophysiology. Mitochondrial electron transport chain …

The entry of calcium into mitochondria is central to metabolism, inter-organelle
communication, and cell life/death decisions. Long-sought transporters involved in …

Lithium carbonate, a drug for the treatment of bipolar disorder, provides mood stability to
mitigate recurrent episodes of mania and/or depression. Despite its long-term and …

Calcium handling by mitochondria is a key feature in cell life. It is involved in energy
production for cell activity, in buffering and shaping cytosolic calcium rises and also in …

Ten years ago, in collaboration with a colleague, I was a Guest Editor of a Clinical
Neuroscience Research special issue “Lithium and Mood Stabilizers: Mechanism of Action” …

Recent advances in cellular and molecular biology have resulted in the identification of two
novel, hitherto completely unexpected targets of lithium's actions, discoveries that may have …