Benign prostatic hyperplasia complicated with T1DM can be alleviated by treadmill exercise—evidences revealed by the rat model

KC Chen, SY Sung, YT Lin, CL Hsieh, KH Shen… - BMC urology, 2015 - Springer
Background Both benign prostatic hyperplasia (BPH) and Type-1 diabetes mellitus (T1DM)
share similar epidemiologic features and are all associated with the insulin-like growth factor …

Aerobic exercise ameliorates benign prostatic hyperplasia in obese mice through downregulating the AR/androgen/PI3K/AKT signaling pathway

S Wang, K Li, Z Liu, S Gui, N Liu, X Liu - Experimental Gerontology, 2021 - Elsevier
Objective Emerging evidence has suggested that physical activities can reduce the risk of
benign prostatic hyperplasia (BPH). Here, we evaluated the effect of aerobic exercise in a …

Aerobic exercises ameliorate benign prostatic hyperplasia via IGF-1/IGF-1R/ERK/AKT signalling pathway in prostate tissue of high-fat-diet-fed mice with insulin …

L Nian, G Shukang, W Shasha, L Xiangyun - Steroids, 2021 - Elsevier
This study investigated the changes in the prostate of high-fat diet (HFD)-fed mice with
insulin resistance (IR) and explored the possible mechanisms of the effects of 8-week …

The impact of diabetes type 2 in the pathogenesis of benign prostatic hyperplasia: a review

K Stamatiou, M Lardas, E Kostakos… - Advances in …, 2009 - Wiley Online Library
Introduction. Clinical observation of larger prostate glands in men with diabetes mellitus type
2 led some investigators to hypothesize that an association between these two conditions …

Increased cell proliferation and contractility of prostate in insulin resistant rats: linking hyperinsulinemia with benign prostate hyperplasia

A Vikram, GB Jena, P Ramarao - The Prostate, 2010 - Wiley Online Library
BACKGROUND Obesity, dyslipidemia, Hyperinsulinemia, and insulin resistance (IR) are key
features of metabolic syndrome and are considered as risk factors for benign prostatic …

Diabetes, growth hormone-insulin-like growth factor pathways and association to benign prostatic hyperplasia

Z Wang, AF Olumi - Differentiation, 2011 - Elsevier
Diabetes significantly increases the risk of benign prostatic hyperplasia (BPH) and low
urinary tract symptoms (LUTS). The major endocrine aberration in connection with the …

Diabetes and benign prostatic hyperplasia: emerging clinical connections

AV Sarma, JK Parsons - Current urology reports, 2009 - Springer
Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are
highly prevalent in older men and represent a substantial challenge to public health …

The relationship between the clinical progression of benign prostatic hyperplasia and metabolic syndrome: a prospective study

Y Fu, Z Zhou, B Yang, K Zhang, L He… - Urologia Internationalis, 2016 - karger.com
Objective: To investigate whether metabolic syndrome (MetS) may be associated with the
clinical progression of benign prostatic hyperplasia (BPH). Methods: A total of 525 …

Testosterone regulates smooth muscle contractile pathways in the rat prostate: emphasis on PDE5 signaling

X Zhang, N Zang, Y Wei, J Yin… - American Journal …, 2012 - journals.physiology.org
Testosterone (T) plays a permissive role in the development of benign prostatic hyperplasia
(BPH), and phosphodiesterase 5 inhibitors (PDE5is) have been found to be effective for …

[HTML][HTML] Association of exercise with benign prostatic hyperplasia and lower urinary tract symptoms

YH Lee, DH Kim, JH Yoon, JS Ju - Exercise Science, 2019 - ksep-es.org
PURPOSE Benign prostatic hyperplasia (BPH) is a very common urological disease in older
men, and it typically leads to lower urinary tract symptoms (LUTS). The exact cause of BPH …