Purpose The increase of IOP in POAG is due an increased resistance of aqueous outflow
through the trabecular meshwork (TM). Methods The exact mechanisms leading to the …

Oxidative free radicals and reactive oxygen species (ROS) are able to affect the cellularity of
the human trabecular meshwork (HTM). These findings suggest that intraocular pressure …

Intraocular pressure (IOP) is the critical risk factor for glaucoma, a neurodegenerative
disease and frequent cause of blindness worldwide. As of today, all effective strategies to …

The perturbation of the pro-oxidant/antioxidant balance can lead to increased oxidative
damage, especially when the first line of antioxidant defense weakens with age. Chronic …

Primary open angle glaucoma (OAG) is a multifactorial optic neuropathy characterized by
progressive retinal ganglion cell death and associated visual field loss. OAG is an emerging …

Glaucoma is an optic neuropathy of unknown origin. The most important risk factor for the
disease is an increased intraocular pressure (IOP). Reducing IOP is associated with …

Glaucoma is the second leading cause of blindness worldwide and elevated intraocular
pressure (IOP) is the most important risk factor. High IOP usually occurs as a result of an …

Nitric oxide generated by three distinct enzyme systems appears to play a critical role in
many diverse physiological processes. Using both conventional and immunohistochemical …

The pathophysiology of glaucoma is complex, multifactorial and not completely understood.
Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic …

Both intraocular pressure (IOP) and vascular factors appear to play an important role in the
pathogenesis of glaucomatous optic neuropathy (GON). Arteriosclerosis and its risk factors …