[HTML][HTML] FDX1 regulates leydig cell ferroptosis mediates PM2. 5-induced testicular dysfunction of mice

L Li, Z Pei, R Wu, Y Zhang, Y Pang, H Hu, W Hu… - Ecotoxicology and …, 2023 - Elsevier
Epidemiological studies have established an association between chronic exposure to PM
2.5 and male infertility. However, the underlying mechanisms were not fully revealed. In this …

Riboflavin alleviates fluoride-induced ferroptosis by IL-17A-independent system Xc−/GPX4 pathway and iron metabolism in testicular Leydig cells

X Li, J Yang, E Shi, Y Lu, X Song, H Luo, J Wang… - Environmental …, 2024 - Elsevier
Fluoride is widely found in groundwater, soil, animal and plant organisms. Excessive
fluoride exposure can cause reproductive dysfunction by activating IL-17A signaling …

[HTML][HTML] PM2. 5 exposure at different concentrations and modes induces reproductive toxicity in male rats mediated by oxidative and endoplasmic reticulum stress

H Liu, S Ding, H Nie, Y Shi, W Lai, X Liu, K Li… - Ecotoxicology and …, 2022 - Elsevier
The molecular mechanisms of PM 2.5 exposure in the male reproductive system, have
scarcely been studied. Here, we demonstrate the possible relationship and molecular …

PM2. 5 caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis

J Wang, Z Zhang, F Shi, Y Li, Y Tang, C Liu… - Science of The Total …, 2023 - Elsevier
Abstract Fine particulate matter (PM 2.5) has been reported to cause various types of
damage to male reproductive system, but the research on the underlying mechanisms is still …

Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion

L Zeng, J Zhou, X Wang, Y Zhang, M Wang… - Free Radical Biology and …, 2021 - Elsevier
Ferroptosis is a newly defined programmed cell death pathway characterized by iron
overload and lipid peroxidation. Increasing studies show that autophagy regulates …

PM 2.5 juvenile exposure–induced spermatogenesis dysfunction by triggering testes ferroptosis and antioxidative vitamins intervention in adult male rats

X Liu, Y Ai, M Xiao, C Wang, Z Shu, J Yin, Y Chu… - … Science and Pollution …, 2023 - Springer
PM2. 5 derived from automobile exhaust can cause reproductive impairment in adult males,
but the toxic effects of PM2. 5 exposure on reproductive function in juvenile male rats and its …

[HTML][HTML] Maternal exposure to PM2. 5 disrupting offspring spermatogenesis through induced sertoli cells apoptosis via inhibin B hypermethylation in mice

J Liu, J Huang, L Gao, Y Sang, X Li, G Zhou… - Ecotoxicology and …, 2022 - Elsevier
Abstract Particulate Matter 2.5 (PM 2.5) disrupts endocrine functions and may negatively
affect sperm quality and quantity in males; however, the long-term effects and potential …

Fluorene-9-bisphenol exposure damages the testis in mice through a novel mechanism of ferroptosis

Q Feng, Y Liu, L Zou, M Lei, C Zhu, W Xia - Food and Chemical Toxicology, 2024 - Elsevier
Abstract Fluorene-9-bisphenol (BHPF) is an emerging global endocrine-disrupting chemical
found in numerous household products as a substitute of bisphenol A. Many studies have …

Glyphosate drives autophagy-dependent ferroptosis to inhibit testosterone synthesis in mouse Leydig cells

L Lu, CY Lian, YT Lv, SH Zhang, L Wang… - Science of The Total …, 2024 - Elsevier
Glyphosate (GLY), a widely used herbicide, can adversely affect the male reproductive
health by inhibiting testosterone synthesis. Ferroptosis is a form of iron-dependent oxidative …

[HTML][HTML] Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and …

F Shi, Z Zhang, H Cui, J Wang, Y Wang, Y Tang… - Ecotoxicology and …, 2022 - Elsevier
Sertoli cells play a pivotal role in the complex spermatogenesis process. This study aimed to
investigate the effects of PM 2.5 on Sertoli cells using the TM4 cell line and a real time whole …