Minimizing the damage: repair pathways keep mitochondrial DNA intact
Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …
accurate replication, transmission and preservation of its integrity throughout the life of the …
[PDF][PDF] Mitochondrial DNA repair and damage tolerance
A Stein, EA Sia - Front Biosci (Landmark Ed), 2017 - article.imrpress.com
The accurate maintenance of mitochondrial DNA (mtDNA) is required in order for eukaryotic
cells to assemble a functional electron transport chain. This independently-maintained …
cells to assemble a functional electron transport chain. This independently-maintained …
Maintenance of mitochondrial DNA integrity: repair and degradation
D Kang, N Hamasaki - Current Genetics, 2002 - Springer
Mitochondria have their own genome, which is essential for proper oxidative
phosphorylation and hence for a large part of ATP production in a cell. Although …
phosphorylation and hence for a large part of ATP production in a cell. Although …
DNA repair in mammalian mitochondria: much more than we thought?
P Liu, B Demple - Environmental and molecular mutagenesis, 2010 - Wiley Online Library
For many years, the repair of most damage in mitochondrial DNA (mtDNA) was thought
limited to short‐patch base excision repair (SP‐BER), which replaces a single nucleotide by …
limited to short‐patch base excision repair (SP‐BER), which replaces a single nucleotide by …
Nuclear and mitochondrial DNA repair: similar pathways?
NB Larsen, M Rasmussen, LJ Rasmussen - Mitochondrion, 2005 - Elsevier
Mitochondrial DNA (mtDNA) alterations are implicated in a broad range of human diseases
and alterations of the mitochondrial genome are assumed to be a result of its high …
and alterations of the mitochondrial genome are assumed to be a result of its high …
The maintenance of mitochondrial DNA integrity—critical analysis and update
M Alexeyev, I Shokolenko… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are
constantly damaged by noxious agents. Eukaryotic cells have developed efficient …
constantly damaged by noxious agents. Eukaryotic cells have developed efficient …
Mitochondrial genome maintenance in health and disease
WC Copeland, MJ Longley - DNA repair, 2014 - Elsevier
Human mitochondria harbor an essential, high copy number, 16,569 base pair, circular DNA
genome that encodes 13 gene products required for electron transport and oxidative …
genome that encodes 13 gene products required for electron transport and oxidative …
Mitochondrial DNA maintenance: an appraisal
AT Akhmedov, J Marín-García - Molecular and cellular biochemistry, 2015 - Springer
Mitochondria play a crucial role in a variety of cellular processes ranging from energy
metabolism, generation of reactive oxygen species (ROS), and Ca 2+ handling to stress …
metabolism, generation of reactive oxygen species (ROS), and Ca 2+ handling to stress …
The mitochondrial response to DNA damage
Z Rong, P Tu, P Xu, Y Sun, F Yu, N Tu… - Frontiers in Cell and …, 2021 - frontiersin.org
Mitochondria are double membrane organelles in eukaryotic cells that provide energy by
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …
Mitochondrial DNA integrity: role in health and disease
As the primary cellular location for respiration and energy production, mitochondria serve in
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …