The process of fibrin formation using highly purified fibrinogen and thrombin was studied
using laser fluctuation spectroscopy, a method that rapidly determines particle size in a …

Using laser fluctuation spectroscopy, a technique that measures particle size change in
solution, the kinetics of fibrin clot formation from fibrinogen can be studied. With this …

The fibrin polymers formed in solution during the earliest phase of the fibrinogen–fibrin
conversion are shown to be stable soluble molecules at pH7. 4 and 0.15 m-or 0.3 m-NaCl …

Fibrin formation from fibrin monomer (FM) complexes was studied in experimental animals
utilizing a previously described technique for quantitating fibrin deposition. A uniform …

Soluble fibrin is observed in patients with intravascular coagulation and represents an
intermediary product of conversion of fibrin monomers into a fibrin clot whereby the …

Fibrinogen is a complex multifunctional protein comprised of three major domains (two outer
D and one central E) which contains constitutive binding sites (eg Da, Db,[gamma] XL, D …

Fibrinogen is a large glycoprotein, synthesized primarily in the liver. With a normal plasma
concentration of 1.5–3.5 g/L, fibrinogen is the most abundant blood coagulation factor. The …

Incubation of fibrinogen with small amounts of thrombin resulted in the occurrence of soluble
fibrin monomer complexes. These complexes consisted predominantly of a derivative with a …

The inhibition of blood clotting by degradation products of fibrinogen reflects an interference
with fibrin network formation. The original discovery that digestion of fibrinogen by plasmin …

Institut Laue-Langevin, 38042 Grenoble Cedex, France, and Max-Planck-Institut fur
Festkorperforschung, Hochfeld-magnetlabor, 38042 Grenoble Cedex, France Received …