Graph and image are two common representations of Hi-C cis-contact maps. Existing
computational tools have only adopted Hi-C data modeled as unitary data structures but …

Accurately predicting chromatin loops from genome-wide interaction matrices such as Hi-C
data is critical to deepening our understanding of proper gene regulation. Current …

In recent years, major advances have been made in various chromosome conformation
capture technologies to further satisfy the needs of researchers for high-quality, high …

Motivation In recent years, there have been significant advances in various chromatin
conformation capture techniques, and annotating the topological structure from Hi-C contact …

Abstract Single‐cell Hi‐C (scHi‐C) has made it possible to analyze chromatin organization
at the single‐cell level. However, scHi‐C experiments generate inherently sparse data …

Hi-C is commonly used to study three-dimensional genome organization. However, due to
the high sequencing cost and technical constraints, the resolution of most Hi-C datasets is …

Motivation High throughput chromosome conformation capture (Hi-C) contact matrices are
used to predict 3D chromatin structures in eukaryotic cells. High-resolution Hi-C data are …

We present Mustache, a new method for multi-scale detection of chromatin loops from Hi-C
and Micro-C contact maps. Mustache employs scale-space theory, a technical advance in …

Hi-C analysis provides valuable insights into the spatial organization of chromatin, which
affects many aspects of genomic processes. However, the usefulness of Hi-C is hindered by …

Recently, Hi-C has been used to probe the 3D chromatin architecture of multiple organisms
and cell types. The resulting collections of pairwise contacts across the genome have …