Abstract “Salty taste” sensation is evoked when sodium and chloride ions are present
together in the oral cavity. The presence of an epithelial cation channel that receives Na+ …

Specialized Ca 2+-dependent ion channels ubiquitously couple intracellular Ca 2+ signals
to a change in cell polarization. The existing physiological evidence suggests that Ca 2+ …

Current evidence suggests salt taste transduction involves at least two mechanisms, one
that is amiloride sensitive and appears to use apically located epithelial sodium channels …

The taste is biologically of intrinsic importance. It almost momentarily perceives
environmental stimuli for better survival. In the early 2000s, research into taste reception was …

Taste bud cells are epithelial cells with neuronal properties. Voltage-dependent ion
channels have been physiologically described in these cells. Here, we report the molecular …

The purpose of this study was to investigate the influence of anion size and the contribution
of the epithelial sodium channel (ENaC) and the transient receptor potential vanilloid-1 …

How taste buds detect NaCl remains poorly understood. Among other problems, applying
taste-relevant concentrations of NaCl (50–500 mm) onto isolated taste buds or cells exposes …

The amiloride‐insensitive salt taste receptor is the predominant transducer of salt taste in
some mammalian species, including humans. The physiological, pharmacological and …

Effects of cathodal current, which draws cations away from the tongue and drives anions
toward the tongue, depend on the ionic content of electrolytes through which the current is …

Genetic ablation of calcium homeostasis modulator 1 (CALHM1), which releases adenosine
triphosphate from Type 2 taste cells, severely compromises the behavioral and …