Deciphering the Crucial Roles of the Quorum-Sensing Transcription Factor SdiA in NADPH Metabolism and (S)-Equol Production in Escherichia coli Nissle 1917

Z Wang, Y Dai, F Azi, M Dong, X Xia - Antioxidants, 2024 - mdpi.com
The active metabolite (S)-equol, derived from daidzein by gut microbiota, exhibits superior
antioxidative activity compared with its precursor and plays a vital role in human health. As …

A gnotobiotic mouse model with divergent equol-producing phenotype: potential for determining microbial-driven health impacts of soy isoflavone daidzein

TWL Cross, LM Leonard, AMR Simpson, L Reddivari - bioRxiv, 2024 - biorxiv.org
The implications of soy consumption on human health have been a subject of debate,
largely due to the mixed evidence regarding its benefits and potential risks. The variability in …

A Gnotobiotic Mouse Model with Divergent Equol-Producing Phenotypes: Potential for Determining Microbial-Driven Health Impacts of Soy Isoflavone Daidzein

LM Leonard, AMR Simpson, S Li, L Reddivari… - Nutrients, 2024 - mdpi.com
The implications of soy consumption on human health have been a subject of debate,
largely due to the mixed evidence regarding its benefits and potential risks. The variability in …

Engineering Escherichia coli for Conversion of Dietary Isoflavones in the Gut

LN Kydd, P Shiveshwarkar, J Jaworski - ACS Synthetic Biology, 2022 - ACS Publications
Introducing metabolic pathways to the gut is important to tailor the biochemical components
ultimately absorbed by the host. Given identical diets, hosts possessing different consortia of …

Exploring functional genes' correlation with (S)-equol concentration and new daidzein racemase identification

YF Hu, S Luo, SQ Wang, KX Chen… - Applied and …, 2024 - Am Soc Microbiol
With its estrogenic activity,(S)-equol plays an important role in maintaining host health and
preventing estrogen-related diseases. Exclusive production occurs through the …

[HTML][HTML] The dietary intervention of synbiotic preparation promotes the bioconversion of soy isoflavones to equol and its metabolic mechanism

X Wang, Y Ma, X Wu, B Chen, X Fang, Q Zhong… - Journal of Functional …, 2023 - Elsevier
Soy isoflavones (SI) undergo biotransformation into equol (EQ) by gut microbiota and equol
exhibits higher bioactivity than soy isoflavones. As a result, the endogenous equol …

Biosynthesis of (S)-Equol from Soy Whey by Metabolically Engineered Escherichia coli

Z Wang, X Li, F Azi, Y Dai, Z Xu, L Yu… - Journal of Agricultural …, 2023 - ACS Publications
(S)-Equol is one of the most bioactive metabolites of the isoflavones with immense
nutritional and pharmaceutical value. Soy whey is the major liquid byproduct of the soy …

[HTML][HTML] Effect of Fermented Soy Beverage on Equol Production by Fecal Microbiota

A Ruiz de la Bastida, S Langa, JA Curiel, Á Peirotén… - Foods, 2024 - mdpi.com
Soy consumption is associated with health benefits, mainly linked to the ability of the
intestinal microbiota to metabolize the glycosylated isoflavones into more bioactive …

[HTML][HTML] AHL-mediated quorum sensing to regulate bacterial substance and energy metabolism: A review

L Liu, X Zeng, J Zheng, Y Zou, S Qiu, Y Dai - Microbiological Research, 2022 - Elsevier
Substance and energy metabolism are the basis for all life activities and are largely
regulated by cell-to-cell communication. Microbial cell-to-cell communication often occurs by …

[HTML][HTML] Inhibitory effects of artificial sweeteners on bacterial quorum sensing

V Markus, O Share, M Shagan, B Halpern… - International journal of …, 2021 - mdpi.com
Despite having been tagged as safe and beneficial, recent evidence remains inconclusive
regarding the status of artificial sweeteners and their putative effects on gut microbiota. Gut …