Polymyxins are polycationic antimicrobial peptides that are currently the last-resort
antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections. The …

Abstract Purpose of Review The polymyxins are one of the last line antimicrobial classes to
retain activity against multidrug-resistant Gram-negative bacilli. However, with the increased …

Infections caused by multi-drug resistant (MDR) bacterial pathogens are a leading cause of
mortality and morbidity across the world. Indiscriminate use of broad-spectrum antibiotics …

Multidrug resistance in pathogens is an increasingly significant threat for human health.
Indeed, some strains are resistant to almost all currently available antibiotics, leaving very …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

Polymyxin antibiotics are increasingly being used as last-line therapeutic options against a
number of multidrug resistant bacteria. These antibiotics show strong bactericidal activity …

Antibiotic resistance among pathogenic bacteria is an ever-increasing issue worldwide.
Unfortunately, very little has been achieved in the pharmaceutical industry to combat this …

Over the last several decades, bacterial resistance generated through the misuse of
antibiotics has been overcome by the development of new, safe, and effective antibiotics …

The emerging very multiresistant Gram-negative bacteria cause remarkable therapeutic
challenges. There are no novel classes of agents in clinical development for the treatment of …