The pineal hormone melatonin is secreted with a marked circadian rhythm. Normally,
maximum production occurs during the dark phase of the day and the duration of secretion …

The role exerted by melatonin in human physiology has not been completely ascertained.
Melatonin levels have been measured in different physiopathological conditions, but the …

The isolation of melatonin was first reported in 1958. Since the demonstration that pineal
melatonin synthesis reflects both daily and seasonal time, melatonin has become a key …

Descriptions of the pineal gland date back to antiquity, but its functions in humans are still
poorly understood. In both diurnal and nocturnal vertebrates, its main product, the hormone …

The photoperiodic message that the pineal gland conveys to the organism is encoded in the
circadian melatonin rhythm. Melatonin is a ubiquitously acting hormone that mediates …

The circadian rhythm of pineal melatonin is the best marker of internal time under low
ambient light levels. The endogenous melatonin rhythm exhibits a close association with the …

The pineal gland was described as the “Seat of the Soul” by Renee Descartes and it is
located in the center of the brain. The main function of the pineal gland is to receive …

Melatonin signals time of day and time of year in mammals by virtue of its pattern of
secretion, which defines 'biological night.'It is supremely important for research on the …

The pineal hormone melatonin is a popular treatment for sleep and circadian rhythm
disruption. Melatonin administered at optimal times of the day for treatment often results in a …

Circadian production and secretion of melatonin from mammalian pineal gland provides
animals with information concerning the light/dark environment. Melatonin passes easily …