Nephropathies arise from conditions that alter nephron development or trigger nephron
damage during neonatal, juvenile, and adult stages of life. Much evidence suggests that a …

The adult kidney has a remarkable ability to survive injury and restore function despite a
limited turnover of cells under physiologic conditions. This accounts both for the tubular and …

Following kidney injury, repair can result in functional tissue becoming a patch of cells and
disorganized extracellular matrix—a scar—or it can recapitulate the original tissue …

The mammalian kidney is a highly complex organ, composed of various cell types within a
unique structural framework. Nonetheless, in recent years, giant leaps in our understanding …

The ability of the human kidney to repair itself is limited. Consequently, repeated injury can
trigger a maladaptive response that is characterized by fibrosis and loss of renal function …

Chronic kidney disease represents a major health problem worldwide. Although the kidney
has the ability to repopulate structures that have sustained some degree of injury, the …

The mammalian renal organ represents a pinnacle of complexity, housing functional filtering
units known as nephrons. During embryogenesis, the depletion of niches containing renal …

Low nephron number—resulting, for example, from prematurity or developmental anomalies—
is a risk factor for the development of hypertension, chronic kidney disease and kidney …

The aim of this study was to better define, by immunohistochemistry, the molecular markers
of renal stem/progenitor cells localized in the different niches of ten human preterm kidneys …

Strategies to facilitate repair or generate new nephrons are exciting prospects for acute and
chronic human renal disease. Repair of kidney injury involves not just local mechanisms but …