Differences in neurotropism and neurotoxicity among retrograde viral tracers

L Sun, Y Tang, K Yan, J Yu, Y Zou, W Xu, K Xiao… - Molecular …, 2019 - Springer
Background Neurotropic virus-based tracers have been extensively applied in mapping and
manipulation of neural circuits. However, their neurotropic and neurotoxic properties remain …

Viral vectors for neural circuit mapping and recent advances in trans-synaptic anterograde tracers

X Xu, TC Holmes, MH Luo, KT Beier, GD Horwitz… - Neuron, 2020 - cell.com
Viral tracers are important tools for neuroanatomical mapping and genetic payload delivery.
Genetically modified viruses allow for cell-type-specific targeting and overcome many …

AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction

Z Han, N Luo, W Ma, X Liu, Y Cai, J Kou… - Nature …, 2023 - nature.com
Viral tracers that enable efficient retrograde labeling of projection neurons are powerful
vehicles for structural and functional dissections of the neural circuit and for the treatment of …

Comparative analyses of transgene expression patterns after intra‐striatal injections of rAAV2‐retro in rats and rhesus monkeys: A light and electron microscopic study

DL Albaugh, Y Smith, A Galvan - European Journal of …, 2020 - Wiley Online Library
Retrogradely‐transducing viral vectors are versatile tools for anatomical and functional
interrogations of neural circuits. These vectors can be applied in nonhuman primates …

Rabies virus pseudotyped with CVS-N2C glycoprotein as a powerful tool for retrograde neuronal network tracing

X Zhu, K Lin, Q Liu, X Yue, H Mi, X Huang, X He… - Neuroscience …, 2020 - Springer
Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are
crucial in structural and functional studies of the brain. The SAD strain rabies virus with the …

Brain-wide TVA compensation allows rabies virus to retrograde target cell-type-specific projection neurons

Z Han, N Luo, J Kou, L Li, Z Xu, S Wei, Y Wu, J Wang… - Molecular Brain, 2022 - Springer
Retrograde tracers based on viral vectors are powerful tools for the imaging and
manipulation of upstream neural networks projecting to a specific brain region, and they play …

Untangling neural networks with dual retrograde transsynaptic viral infection

S Ohara, K Inoue, MP Witter, T Iijima - Frontiers in Neuroscience, 2009 - frontiersin.org
Using recombinant rabies virus (RV), we developed a dual transsynaptic retrograde tracing
technique in the rat central nervous system. Two strains of recombinant RV, injected into two …

Dual transneuronal tracing in the rat entorhinal-hippocampal circuit by intracerebral injection of recombinant rabies virus vectors

S Ohara, K Inoue, M Yamada, T Yamawaki… - Frontiers in …, 2009 - frontiersin.org
Dual transneuronal tracing is a novel viral tracing methodology which employs two
recombinant viruses, each expressing a different reporter protein. Peripheral injection of …

A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing

KZ Lin, L Li, WY Ma, X Yang, ZP Han… - Neural Regeneration …, 2023 - journals.lww.com
Analyzing the structure and function of the brain's neural network is critical for identifying the
working principles of the brain and the mechanisms of brain diseases. Recombinant rabies …

Single-cell analysis of neuroinflammatory responses following intracranial injection of G-deleted rabies viruses

KW Huang, BL Sabatini - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Viral vectors are essential tools for the study of neural circuits, with glycoprotein-deleted
rabies viruses being widely used for monosynaptic retrograde tracing to map connectivity …