Background: Interferon-γ–release assays (IGRAs) are alternatives to the tuberculin skin test
(TST). A recent meta-analysis showed that IGRAs have high specificity, even among …

Background: Until recently, the tuberculin skin test was the only test for detecting latent
tuberculosis (TB) infection, but 2 ex vivo interferon-γ release assays (IGRAs) are now …

Interferon-γ release assays (IGRAs) are now established for the immunodiagnosis of latent
infection with Mycobacterium tuberculosis in many countries. However, the role of IGRAs for …

Targeted testing and treatment of individuals with latent tuberculosis infection at increased
risk of progression to active disease is a key element of tuberculosis control. This strategy is …

Test accuracy of interferon-γ release assays (IGRAs) for diagnosing TB differs when using
older or precommercial tools and inconsistent diagnostic criteria. This metaanalysis critically …

We conducted a systematic review and meta-analysis to compare the accuracy of the
QuantiFERON-TB® Gold In-Tube (QFT-G-IT) and the T-SPOT®. TB assays with the …

Interferon-release assays (IGRAs) represent advances in tuberculosis immunology and
evolutionary biology. IGRAs were designed to replace tuberculin skin test (TST) for the …

Background Accurate diagnosis and subsequent treatment of latent tuberculosis infection
(LTBI) is essential for TB elimination. However, the absence of a gold standard test for …

Screening for active tuberculosis (TB) and latent TB infection (LTBI) is mandatory prior to the
initiation of tumour necrosis factor-α inhibitor therapy. However, no agreement exists on the …

Until recently, the only tool available to detect latent tuberculosis infection (LTBI) was the
tuberculin skin test (TST). Although the TST has proven to be useful in clinical practice, it has …