Bone grafts are one of the most commonly transplanted tissues. However, autologous grafts
are in short supply, and can be associated with pain and donor-site morbidity. The creation …

In regenerative medicine, techniques which control stem cell lineage commitment are a
rapidly expanding field of interest. Recently, nanoscale mechanical stimulation of …

There is a pressing clinical need to develop cell-based bone therapies due to a lack of
viable, autologous bone grafts and a growing demand for bone grafts in musculoskeletal …

Mechanical signals are ubiquitous in our everyday life and the process of converting these
mechanical signals into a biological signalling response is known as mechanotransduction …

It is likely that mesenchymal stem cells will find use in many autologous regenerative
therapies. However, our ability to control cell stem growth and differentiation is presently …

The application of physical stimuli to cell cultures has shown potential to modulate multiple
cellular functions including migration, differentiation and survival. However, the relevance of …

As a strategy to optimise osteointegration of biomaterials by inducing proper extracellular
matrix synthesis, and specifically angiogenic growth factor production and storage, we …

In the past decades, bone tissue engineering developed and exploited many typologies of
bioreactors, which, besides providing proper culture conditions, aimed at integrating those …

Bioactive metabolites have wide-ranging biological activities and are a potential source of
future research and therapeutic tools. Here, we use nanovibrational stimulation to induce …

Although in vivo studies have shown that low-magnitude, high-frequency (LMHF) vibration
(LM:< 1× g; HF: 20-90 Hz) exhibits anabolic effects on skeletal homeostasis, the underlying …