The 2022 WHO classification reflects increases in the knowledge of the underlying
pathogenesis of parathyroid disease. In addition to the classic characteristic features of …

Background The histopathological criteria for carcinoma proposed by the World Health
Organization (WHO) are imperfect predictors of the malignant potential of parathyroid …

BACKGROUND: It is frequently difficult to establish histologically whether a parathyroid
tumor is a parathyroid carcinoma, parathyromatosis, or an atypical adenoma. The authors …

Parathyroid carcinoma is a rare type of endocrine cancer, with significant morbidity and
mortality associated with parathyroid hormone (PTH)-mediated hypercalcemia. Concerning …

The majority of parathyroid disease encountered in routine practice is due to single
parathyroid adenoma, of which the majority arise as sporadic tumors. This is usually a …

Background Parathyroid cancer is rare. Differentiating parathyroid carcinoma from
degenerative changes at histopathology can be difficult and studies investigating the value …

The gene CDC73 (previously known as HRPT2) encodes the protein parafibromin. Biallelic
mutation of CDC73 is strongly associated with malignancy in parathyroid tumors …

Pathologists are usually readily able to diagnose parathyroid tissues and diseases,
particularly when they have knowledge of the clinical information, laboratory findings, and …

Proliferative pathologic lesions of parathyroid glands encompass a spectrum of entities
ranging from benign hyperplastic processes to malignant neoplasia. This review article …

Parathyroid neoplasms encompass a spectrum of proliferative lesions that include
adenomas, atypical adenomas, and carcinomas. While the diagnosis of adenomas is …