Alternative splicing, a driver of posttranscriptional variance, differs from canonical splicing by
arranging the introns and exons of an immature pre-mRNA transcript in a multitude of …

Alternative splicing is an important mechanism used by the cell to generate greater
transcriptomic and proteomic diversity from the genome. In the heart, alternative splicing is …

RNA splicing represents a post-transcriptional mechanism to generate multiple functional
RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example …

Alternative splicing is the main driver of protein diversity and allows the production of
different proteins from each gene in the genome. Changes in exon exclusion, intron …

Despite advances in therapeutics for heart failure and arrhythmias, a substantial proportion
of patients with cardiomyopathy do not respond to interventions, indicating a need to identify …

Following the original reports of pre‐mRNA splicing in 1977, it was quickly realized that
splicing together of different combinations of splice sites–alternative splicing–allows …

Apoptosis is required for normal heart development in the embryo, but has also been shown
to be an important factor in the occurrence of heart disease. Alternative splicing of apoptotic …

Alternative splicing (AS) drives determinative changes during mouse heart development.
Recent high-throughput technological advancements have facilitated genome-wide AS …

Alternative splicing generates specialized protein isoforms that allow the heart to adapt
during development and disease. The recent discovery that mutations in the splicing factor …

Background—Alternative mRNA splicing is an important mechanism for regulation of gene
expression. Altered mRNA splicing occurs in association with several types of cancer, and a …