[HTML][HTML] From mitochondria to sarcopenia: role of 17β-estradiol and testosterone

X Tian, S Lou, R Shi - Frontiers in Endocrinology, 2023 - frontiersin.org
Sarcopenia, characterized by a loss of muscle mass and strength with aging, is prevalent in
older adults. Although the exact mechanisms underlying sarcopenia are not fully …

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

E Marzetti, R Calvani, M Cesari, TW Buford… - The international journal …, 2013 - Elsevier
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …

[HTML][HTML] Mitochondrial impairment in sarcopenia

F Bellanti, A Lo Buglio, G Vendemiale - Biology, 2021 - mdpi.com
Simple Summary With old age, the strength and size of our muscles worsens with time,
affecting our ability to carry out daily activities. Muscle wasting may be more dangerous for …

[HTML][HTML] Update on mitochondria and muscle aging: all wrong roads lead to sarcopenia

A Picca, R Calvani, M Bossola, E Allocca… - Biological …, 2018 - degruyter.com
Sarcopenia is a well-known geriatric syndrome that has been endorsed over the years as a
biomarker allowing for the discrimination, at a clinical level, of biological from chronological …

[HTML][HTML] The contribution of mitochondria to age-related skeletal muscle wasting: A sex-specific perspective

A Nuccio, R Nogueira-Ferreira, A Moreira-Pais… - Life Sciences, 2023 - Elsevier
As people age, their skeletal muscle (SkM) experiences a decline in mitochondrial
functionality and density, which leads to decreased energy production and increased …

Skeletal muscle aging and the mitochondrion

ML Johnson, MM Robinson, KS Nair - Trends in endocrinology & …, 2013 - cell.com
Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging
process. A growing body of research in the areas of bioenergetics and protein turnover has …

Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction

AM Abbatecola, G Paolisso, P Fattoretti… - The journal of nutrition …, 2011 - Springer
The precise cause of sarcopenia, skeletal muscle loss and strength, in older persons is
unknown. However, there is a strong evidence for muscle loss due to insulin resistance as …

Searching for a mitochondrial root to the decline in muscle function with ageing

M Gonzalez‐Freire, F Adelnia… - Journal of cachexia …, 2018 - Wiley Online Library
Sarcopenia, the age‐related loss of muscle mass and strength, is linked to a range of
adverse outcomes, such as impaired physical performance, cognitive function, and mortality …

[HTML][HTML] Role of age-related mitochondrial dysfunction in sarcopenia

E Ferri, E Marzetti, R Calvani, A Picca, M Cesari… - International journal of …, 2020 - mdpi.com
Skeletal muscle aging is associated with a significant loss of skeletal muscle strength and
power (ie, dynapenia), muscle mass and quality of life, a phenomenon known as …

Mitochondrial ROS and aging: understanding exercise as a preventive tool

HS Brunetta, AM Holwerda, LJC van Loon… - Journal of Science in …, 2020 - Springer
Sarcopenia, which is characterized by reduction in muscle mass and strength, contributes to
several age-related conditions, including insulin resistance and frailty. Despite the …