Vascular, resident stem cells are present in all 3 layers of the vessel wall; they play a role in
vascular formation under physiological conditions and in remodeling in pathological …

The fundamental contributions that blood vessels make toward organogenesis and tissue
homeostasis are reflected by the considerable ramifications that loss of vascular wall …

Throughout development and adult life the vasculature exhibits a remarkably dynamic
capacity for growth and repair. The vasculature also plays a pivotal role in the execution of …

Stem cells in adult organs reside in specialized niches that regulate their proliferation and
differentiation. Investigations during the last few years have unveiled a regulatory role for …

The vessel wall has usually been thought to be relatively quiescent. But the discovery of
progenitor cells in many tissues and in the vasculature itself has led to a reconsideration of …

Exuberant accumulation of smooth muscle cells (SMCs) plays a principal role in the
pathogenesis of vascular diseases. It has been assumed that SMCs derived from the …

New blood vessels are formed through angiogenesis and postnatal vasculogenesis. Thus, it
is essential to identify vascular stem and progenitor cell niches and the mechanisms …

Vasculogenesis, the in‐situ assembly of angioblast or endothelial progenitor cells (EPCs),
may persist into adult life, contributing to new blood vessel formation. However, EPCs are …

Homeostasis of the vessel wall is essential for maintaining its function, including blood
pressure and patency of the lumen. In physiological conditions, the turnover rate of vascular …

The recent discovery of progenitor cells in peripheral blood that can differentiate into
endothelial or vascular smooth muscle cells has led to the re-evaluation of many traditionally …