Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …
for delivering amorphous drugs with poor water solubilities, and they have gained great …
Physical stability of amorphous pharmaceutical solids: Nucleation, crystal growth, phase separation and effects of the polymers
Q Shi, F Li, S Yeh, Y Wang, J Xin - International journal of pharmaceutics, 2020 - Elsevier
Compared to their crystalline forms, amorphous pharmaceutical solids present marvelous
potential and advantages for effectively improving the oral bioavailability of poorly water …
potential and advantages for effectively improving the oral bioavailability of poorly water …
Polymeric amorphous solid dispersions: a review of amorphization, crystallization, stabilization, solid-state characterization, and aqueous solubilization of …
S Baghel, H Cathcart, NJ O'Reilly - Journal of pharmaceutical sciences, 2016 - Elsevier
Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …
Polymeric solid dispersion Vs co-amorphous technology: A critical comparison
Historically, amorphous solid dispersion technology with polymeric carriers has been
employed to stabilize high-energy amorphous phases of poorly water-soluble drug …
employed to stabilize high-energy amorphous phases of poorly water-soluble drug …
Excipients for amorphous solid dispersions
Pharmaceutical excipients play a significant role in stabilization of amorphous solid
dispersions, as these systems are thermodynamically unstable. This chapter illustrates the …
dispersions, as these systems are thermodynamically unstable. This chapter illustrates the …
Overview of amorphous solid dispersion technologies
H Sandhu, N Shah, H Chokshi, AW Malick - Amorphous solid dispersions …, 2014 - Springer
Successful development of amorphous solid dispersion formulations depends on three
primary factors: active pharmaceutical ingredient properties, stabilizing polymer, and the …
primary factors: active pharmaceutical ingredient properties, stabilizing polymer, and the …
Amorphous solid dispersions: a robust platform to address bioavailability challenges
A Newman, K Nagapudi, R Wenslow - Therapeutic delivery, 2015 - Taylor & Francis
Amorphous solid dispersions (ASDs) are being used with increasing frequency for poorly
soluble pharmaceutical compounds in development. These systems consist of an …
soluble pharmaceutical compounds in development. These systems consist of an …
Co-amorphous Drug Delivery Systems: a Review of Physical Stability, In Vitro and In Vivo Performance
Q Shi, Y Wang, SM Moinuddin, X Feng, F Ahsan - AAPS PharmSciTech, 2022 - Springer
Over the past few decades, co-amorphous solids have been used as a promising approach
for delivering poorly water-soluble drugs. Co-amorphous solids, comprising …
for delivering poorly water-soluble drugs. Co-amorphous solids, comprising …
Amorphous active pharmaceutical ingredients in preclinical studies: preparation, characterization, and formulation
K Nagapudi, J Jona - Current Bioactive Compounds, 2008 - ingentaconnect.com
A large number of the new pharmaceutical small molecules under development today are
found to have poor water solubility. This in turn may lead to low bioavailability, which can …
found to have poor water solubility. This in turn may lead to low bioavailability, which can …
Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …