Frailty and depression were linked in observational studies, but the causality remains
ambiguous. We intended to explore it using Mendelian randomization (MR). We obtained …

Frailty is an aging-related clinical phenotype defined as a state in which there is an increase
in a person's vulnerability for dependency and/or mortality when exposed to a stressor …

Background Frailty is strongly associated with cardiometabolic diseases in observational
studies. However, whether the observed association reflects causality requires clarification …

Aim Depression and frailty are prevalent and burdensome in older age. However, the
relationships between these entities are unclear and no quantitative meta-analysis exists …

Background Frailty is a medical syndrome that is strongly associated with mortality risk and
an emerging global health burden. Mental disorders are associated with reduced life …

Frailty is a common geriatric syndrome and strongly associated with disability, mortality and
hospitalization. Frailty is commonly measured using the frailty index (FI), based on the …

Background Previous research demonstrated substantial associations between frailty and
depression in late life, but it remains unclear whether this relationship is best explained by …

Background Physical frailty is a state of increased vulnerability to stressors and is associated
with serious health issues. However, how frailty affects and is affected by numerous other …

Background Dementia is associated with a high burden of dependency and disability.
Physical frailty (hereafter referred to as frailty) is a multisystem dysregulation that has been …

Background Frailty has been identified as a risk factor for cognitive impairment and
dementia. However, it is not known whether familial factors, such as genetics and shared …