An advanced multifunctional prodrug combining photodynamic therapy with chemotherapy for highly efficient and precise tumor ablation

P Hu, G Xu, DC Yang, JY Liu, Z Chen, M Huang - Dyes and Pigments, 2022 - Elsevier
It is urgently required to develop the molecular agents with high therapeutic efficacy and low
side effects for precise cancer therapy. Herein, an advanced multifunctional prodrug B-BDP …

Red light triggered photodynamic-chemo combination therapy using a prodrug caged by photosensitizer

G Xu, HX Zhang, XQ Li, DC Yang, JY Liu - European Journal of Medicinal …, 2021 - Elsevier
Abstract Development of the drug with high therapeutic efficacy and low toxicity is crucial to
cancer ablation. In this study, we have demonstrated a red light-responsive prodrug BDP-TK …

Enzyme-Activated Multifunctional Prodrug Combining Site-Specific Chemotherapy with Light-Triggered Photodynamic Therapy

HX Zhang, HH Lin, D Su, DC Yang… - Molecular …, 2022 - ACS Publications
Combination treatments are more effective than conventional monotherapy in combating
cancer. Herein, a multifunctional prodrug BDP-L-CPT was rationally engineered and …

A promising strategy for synergistic cancer therapy by integrating a photosensitizer into a hypoxia-activated prodrug

DC Yang, XZ Yang, CM Luo, LF Wen, JY Liu… - European Journal of …, 2022 - Elsevier
Herein, we fabricate a multifunctional molecular prodrug BAC where the chemotherapeutical
agent camptothecin (CPT) is linked with a boron dipyrromethene (BODIPY)-based …

A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy

Y Yang, Y Zhang, R Wang, X Rong, T Liu, X Xia… - Chinese Chemical …, 2022 - Elsevier
During cancer treatment, chemotherapeutic drugs always result in severe side-effects and
drug resistance. Therefore, combining cheomtherapy with other therapeutic modalities, such …

Rational Design of Efficient Heavy-Atom-Free Boron-Dipyrromethene Nanophotosensitizers for Two-Photon Excited Photodynamic Therapy of Cancer

VN Nguyen, DJ Lee, D Zhang, J Ha… - Chemistry of …, 2024 - ACS Publications
Although boron-dipyrromethene (BODIPY) dyes have been widely recognized for their
potential use as photosensitizers (PSs) in cancer treatment, the development of heavy-atom …

PEG conjugated BODIPY-Br 2 as macro-photosensitizer for efficient imaging-guided photodynamic therapy

Z Ruan, Y Zhao, P Yuan, L Liu, Y Wang… - Journal of Materials …, 2018 - pubs.rsc.org
Drug-free biocompatible nanoparticles with photosensitizers as both diagnostic and therapy
agents represent an emerging approach for imaging-guided photodynamic therapy (PDT) …

PEGylated dimeric BODIPY photosensitizers as nanocarriers for combined chemotherapy and cathepsin B-activated photodynamic therapy in 3D tumor spheroids

S Lu, X Lei, H Ren, S Zheng, J Qiang… - ACS Applied Bio …, 2020 - ACS Publications
The development of enzyme-activatable photosensitizers and their combination with
conventional chemodrugs for antitumor therapy are of great interest. In this work, we …

A dual activatable photosensitizer toward targeted photodynamic therapy

JTF Lau, PC Lo, XJ Jiang, Q Wang… - Journal of Medicinal …, 2014 - ACS Publications
An unsymmetrical bisferrocenyl silicon (IV) phthalocyanine has been prepared in which the
disulfide and hydrazone linkers can be cleaved by dithiothreitol and acid, respectively. The …

[HTML][HTML] Cell membranes targeted unimolecular prodrug for programmatic photodynamic-chemo therapy

J Yuan, R Peng, D Su, X Zhang, H Zhao, X Zhuang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Photodynamic therapy (PDT) has emerged as one of the most up-and-coming non-invasive
therapeutic modalities for cancer therapy in rencent years. However, its therapeutic effect …