Control of posttranscriptional mRNA decay is a crucial determinant of cell homeostasis and
differentiation. mRNA lifetime is governed by cis-regulatory elements in their 3 …

Roquin function in T cells is essential for the prevention of autoimmune disease. Roquin
interacts with the 3′ untranslated regions (UTRs) of co-stimulatory receptors and controls T …

The RNA-binding protein Roquin is required to prevent autoimmunity. Roquin controls T-
helper cell activation and differentiation by limiting the induced expression of costimulatory …

Post-transcriptional gene regulation controls the amount of protein produced from a specific
mRNA by altering both its decay and translation rates. Such regulation is primarily achieved …

Roquin is an E3 ubiquitin ligase with a poorly understood but essential role in preventing T‐
cell‐mediated autoimmune disease and in microRNA‐mediated repression of inducible …

Posttranscriptional regulation of gene expression plays a central role in the initiation of
innate and adaptive immune responses. This is exemplified by the protein Roquin, which …

Zinc finger (ZnF) domains appear in a pool of structural contexts and despite their small size
achieve varying target specificities, covering single-stranded and double-stranded DNA and …

A conserved stem-loop motif of the constitutive decay element (CDE) in the 3′ UTR of
mRNAs is recognized by the ROQ domain of Roquin, which mediates mRNA degradation …

The RNA-binding proteins Roquin-1 and Roquin-2 redundantly control gene expression and
cell-fate decisions. Here, we show that Roquin not only interacts with stem–loop structures …

Adenylate/uridylate-rich elements (AREs) are the most common cis-regulatory elements in
the 3′-untranslated region (UTR) of mRNAs, where they fine-tune turnover by mediating …